Mackert B M, Burghoff M, Hiss L H, Nordahn M, Trahms L, Curio G
Neurophysics Group, Department of Neurology, Klinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Neurosci Lett. 2000 Jul 28;289(1):33-6. doi: 10.1016/s0304-3940(00)01249-0.
Compound action current (CAC) propagation along nerve fibers running deep in the human brachial plexus was 3D-visualized based on non-invasive 49-channel superconducting quantum interference device (SQUID) magnetoneurography. Spatio-temporal mappings over the upper thoracal quadrant of magnetic fields (<100 fT) evoked upon alternating median and ulnar nerve stimulation in seven healthy volunteers showed consistently smoothly propagating dipolar patterns for both the CAC depolarization and repolarization phases. Multipolar current source reconstructions (i) distinguished spatially CAC propagation pathways along either median or ulnar plexus fibers, allowed (ii) to calculate local conduction velocities ( approximately 56 m/s) and (iii) even to estimate the CAC extension along the nerve fibers (depolarization phase: approximately 11 cm). Thus, for deep proximal nerve segments magnetoneurography can provide a detailed tracing of neural activity which is a prerequisite to localize non-invasively focal nerve malfunctions.
基于非侵入性49通道超导量子干涉装置（SQUID）磁神经图，对沿人类臂丛神经深部走行的神经纤维上的复合动作电流（CAC）传播进行了三维可视化。在7名健康志愿者中，对正中神经和尺神经进行交替刺激时，对上胸象限磁场（<100 fT）进行时空映射，结果显示，对于CAC去极化和复极化阶段，均始终呈现出平滑传播的偶极模式。多极电流源重建（i）在空间上区分了沿正中或尺神经丛纤维的CAC传播路径，（ii）能够计算局部传导速度（约56米/秒），（iii）甚至能够估计CAC沿神经纤维的延伸长度（去极化阶段：约11厘米）。因此，对于深部近端神经节段，磁神经图可以提供神经活动的详细追踪，这是非侵入性定位局灶性神经功能障碍的先决条件。
