Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Curr Biol. 2019 Oct 7;29(19):3177-3192.e3. doi: 10.1016/j.cub.2019.07.089. Epub 2019 Sep 19.
The lateral septum (LS) has been implicated in anxiety and fear modulation and may regulate interactions between the hippocampus and regions, such as the VTA, that mediate goal-directed behavior. In this study, we simultaneously record from cells in the LS and the hippocampus during navigation and conditioning tasks. In the LS, we identify a speed and acceleration spiking code that does not map to states of anticipation or reward. Additionally, we identify an overlapping population of LS cells that change firing to cue and reward during conditioning. These cells display sharp wave ripple and theta modulation, spatial firing fields, and responses similar to the hippocampus during conditioning. These hippocampus-associated cells are not disproportionately speed or acceleration modulated, suggesting that these movement correlates are not hippocampally derived. Finally, we show that LS theta coordination is selectively enhanced in hippocampus-associated LS cells during navigation behavior that requires working memory. Taken together, these results suggest a role for the LS in transmitting spatial and contextual information, in concert with locomotor information, to downstream areas, such as the VTA, where value weighting may take place.
外侧隔核（LS）被认为与焦虑和恐惧调节有关，可能调节海马体与 VTA 等介导目标导向行为的区域之间的相互作用。在这项研究中，我们在导航和条件反射任务期间同时记录 LS 和海马体中的细胞。在 LS 中，我们发现了一种不映射到预期或奖励状态的速度和加速度尖峰编码。此外，我们还发现了一个重叠的 LS 细胞群体，它们在条件反射过程中对线索和奖励的反应发生变化。这些细胞显示出尖锐波涟漪和 theta 调制、空间发射场以及在条件反射过程中与海马体相似的反应。这些与海马体相关的细胞不受速度或加速度的不成比例调制，这表明这些运动相关物不是海马体衍生的。最后，我们发现，在需要工作记忆的导航行为中，LS 中的 theta 协调选择性地增强了与海马体相关的 LS 细胞。总之，这些结果表明 LS 在将空间和上下文信息与运动信息一起传递到下游区域（如 VTA）中发挥作用，在 VTA 中可能会发生价值加权。
