探索阿奇唑大环化合物的关环复分解方法。
Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle.
作者信息
King Brianne R, Swick Steven M, Schaefer Sara L, Welch Jamie R, Hunter Emily F, O'Neil Gregory W
机构信息
Department of Chemistry, Western Washington University, Bellingham, WA 98225.
出版信息
Synthesis (Stuttg). 2014 Nov;46(21):2927-2936. doi: 10.1055/s-0034-1379003. Epub 2014 Aug 15.
Abstract
The synthesis of a new "eastern domain" of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by RCM. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay.
摘要
本文描述了一种拟议的二氢阿扎唑烷类似物新“东部区域”的合成，以及通过RCM进行大环化尝试的初步结果。这项工作揭示了一个竞争性的分子内回咬过程，通过醇官能化和安装复分解中继可能可以防止该过程。
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