Xu Li, Yu Ru-Jing, Ding Xu-Ming, Li Mao, Wu Yue, Zhu Li, Chen Di, Peng Cheng, Zeng Chang-Juan, Guo Wen-Yi
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China.
Int J Ophthalmol. 2019 Sep 18;12(9):1432-1437. doi: 10.18240/ijo.2019.09.10. eCollection 2019.
To investigate the efficacy of low-energy selective laser trabeculoplasty (SLT) on the treatment of primary open angle glaucoma (POAG) patients.
Outpatients with POAG who underwent 360-degree SLT using an initial energy of 0.3 mJ (total energy of 30-40 mJ) were reviewed retrospectively from September 2011 to January 2018.
Eight-six eyes of 44 POAG patients underwent 360-degree SLT using initial energy of 0.3 mJ and were followed up regularly. The total energy used was 32.5±2.5 mJ (23-40 mJ, 105±6 spots). The average pretreatment intraocular pressure (IOP) was 19.8±3.9 mm Hg. At 1, 3, 6mo, 1, and 2y, the post-SLT IOPs (mm Hg) were 16.9±3.3, 16.5±3.3, 17.1±3.4, 16.6±3.5, 16.5±2.8, which were significantly lower than that before treatment (<0.001). The patients in the SLT success group were found to be younger than those in the SLT failure group. After SLT, 59 eyes that maintained pretreatment medications were defined as the drug retention group. The pre-SLT IOP was 20.1±3.7 mm Hg. At 1, 3, 6mo, 1, and 2y, the post-SLT IOPs (mm Hg) were 17.3±3.6, 16.6±3.5, 17.2±3.6, 16.9±3.8 and 16.5±2.9, respectively. Twenty-seven eyes that required reduced drugs were defined as the drug reduction group. The pre-SLT IOP was 19.2±4.4 mm Hg. At 1, 3, 6mo, 1, and 2y, the post-SLT IOPs (mm Hg) were 16.1±2.6, 16.5±3.1, 16.8±2.9, 16.0±2.6 and 16.3±2.4, respectively. Compared with the pretreatment IOPs, the post-SLT IOPs were significantly lower in drug retention group and drug reduction group. The patients in the drug reduction group were found to be younger than those in the drug retention group.
Low-energy SLT is safe and effective for POAG patients during a 2-year follow-up. Younger POAG patients may obtain better results after low-energy SLT treatment.
探讨低能量选择性激光小梁成形术（SLT）治疗原发性开角型青光眼（POAG）患者的疗效。
回顾性分析2011年9月至2018年1月期间接受初始能量为0.3 mJ（总能量30 - 40 mJ）的360度SLT治疗的POAG门诊患者。
44例POAG患者的86只眼接受了初始能量为0.3 mJ的360度SLT治疗，并进行了定期随访。总能量为32.5±2.5 mJ（23 - 40 mJ，105±6个光斑）。治疗前平均眼压（IOP）为19.8±3.9 mmHg。在1个月、3个月、6个月、1年和2年时，SLT术后眼压（mmHg）分别为16.9±3.3、16.5±3.3、17.1±3.4、16.6±3.5、16.5±2.8，均显著低于治疗前（<0.001）。发现SLT成功组患者比SLT失败组患者年轻。SLT术后，59只维持治疗前用药的眼睛被定义为药物保留组。SLT术前眼压为20.1±3.7 mmHg。在1个月、3个月、6个月、1年和2年时，SLT术后眼压（mmHg）分别为17.3±3.6、16.6±3.5、17.2±3.6、16.9±3.8和16.5±2.9。27只需要减少用药的眼睛被定义为药物减量组。SLT术前眼压为19.2±4.4 mmHg。在1个月、3个月、6个月、1年和2年时，SLT术后眼压（mmHg）分别为16.1±2.6、16.5±3.1、16.8±2.9、16.0±2.6和16.3±2.4。与治疗前眼压相比，药物保留组和药物减量组SLT术后眼压均显著降低。发现药物减量组患者比药物保留组患者年轻。
低能量SLT在2年随访期间对POAG患者安全有效。年轻的POAG患者在低能量SLT治疗后可能获得更好的效果。
