全基因组关联研究及后全基因组关联研究时代的近视遗传学
Myopia genetics in genome-wide association and post-genome-wide association study era.
作者信息
Liao Xuan, Tan Qing-Qing, Lan Chang-Jun
机构信息
Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
出版信息
Int J Ophthalmol. 2019 Sep 18;12(9):1487-1492. doi: 10.18240/ijo.2019.09.18. eCollection 2019.
Abstract
Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.
摘要
近视和屈光不正的全基因组关联研究（GWAS）已经产生了令人兴奋的结果，并确定了新的风险相关基因座。然而，对复杂疾病GWAS研究结果的解释并非易事，仍然具有挑战性。本综述简要总结了近视GWAS的主要重点，包括其优势和局限性，以及在GWAS后或组学时代可能有助于进一步深入了解近视遗传学的潜在策略。
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