Pain and Rehabilitation Centre, Department of Medical and Health Sciences, , , Sweden.
J Rehabil Med. 2019 Oct 29;51(10):779-787. doi: 10.2340/16501977-2593.
The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia. Few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides.
To compare plasma levels of nerve growth factor and brain-derived neurotrophic factor in fibromy-algia and in healthy controls, to investigate correlations between levels of nerve growth factor, brain-derived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels.
A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15-week intervention, and 25 healthy controls participated at baseline. Patients were randomized to a 15-week progressive resistance exercise intervention or a relaxation intervention.
Brain-derived neurotrophic factor level was significantly higher (p < 0.001) and nerve growth factor level was significantly lower (p < 0.001) in fibromyalgia than in healthy controls. Neither resistance exercise nor relaxation interventions affected the levels of brain-derived neurotrophic factor or nerve growth factor. No significant correlations were found between brain-derived neurotrophic factor or nerve growth factor plasma levels in fibromyalgia and cytokine levels or clinical variables.
Changes in circulating nerve growth factor and brain-derived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.
纤维肌痛的病理生理学包括中枢和外周因素。神经营养因子，如神经生长因子和脑源性神经营养因子，参与外周和中枢神经系统疼痛和痛觉过敏的发展。很少有研究检查纤维肌痛症患者循环神经生长因子和脑源性神经营养因子，或调查运动干预是否会影响这些肽的水平。
比较纤维肌痛症和健康对照组的血浆神经生长因子和脑源性神经营养因子水平，研究神经生长因子、脑源性神经营养因子和细胞因子与临床变量之间的相关性，并研究运动对这些水平的影响。
共有 75 名女性纤维肌痛症患者在基线和 15 周干预后接受血液检查，25 名健康对照者在基线时接受检查。患者被随机分为 15 周的渐进式抗阻运动干预或放松干预。
纤维肌痛症患者的脑源性神经营养因子水平显著升高（p < 0.001），神经生长因子水平显著降低（p < 0.001）。抗阻运动或放松干预均未影响脑源性神经营养因子或神经生长因子的水平。纤维肌痛症患者的脑源性神经营养因子或神经生长因子血浆水平与细胞因子水平或临床变量之间无显著相关性。
循环神经生长因子和脑源性神经营养因子水平的变化可能影响纤维肌痛症的伤害感受/疼痛。运动干预后可获得临床改善，但脑源性神经营养因子和神经生长因子的水平未恢复正常。
