Taylor Taylor L, Dodds Fitzgerald, Tharpe McKenna, Zumbro Emily L, Hankes Michael, Jones Raymond, Rumble Deanna, Antoine Lisa, Allen-Watts Kristen, Sims Andrew, Chandra Reshu, Goodin Burel R, Younger Jarred, Buford Thomas W
Department of Family and Community Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Hum Neurosci. 2025 Jan 6;18:1463935. doi: 10.3389/fnhum.2024.1463935. eCollection 2024.
Fibromyalgia (FM) is a widespread chronic pain condition with prevalence increasing in older adults. Older adults living with FM experience longer pain symptom durations that can negatively impact their quality of life. Affect and neuroinflammation are potential factors that can exacerbate pain symptoms. Exercise is a recommended intervention to manage pain symptoms; however, adherence limitations persist. Drawing on the Biopsychosocial Framework of Chronic Pain, this scoping review explores how exercise impacts factors related to neuroinflammation and affect, and how these factors contribute to exercise adherence in older adults living with FM.
We conducted a scoping search of articles related to exercise and older adults living with FM published before 2024. The extracted study characteristics include publication type, study design, affect outcomes, neuroinflammation outcomes, exercise type, exercise adherence, and sample demographic information.
We have provided an overview of the relationship between affect and neuroinflammation in studies including older adults living with FM and highlight the impact of exercise on affect and neuroinflammation in older adults living with FM. A conceptual framework is provided illustrating the reciprocal relationship between exercise, affective changes, neuroinflammation, and exercise adherence.
Our results suggest that exercise may improve affect, while limited evidence suggests that aerobic and resistance exercise improve neuroinflammation. Finally, implications for importance and future directions in the context of potential biological factors impacted are provided.
纤维肌痛（FM）是一种广泛存在的慢性疼痛病症，在老年人中的患病率不断上升。患有纤维肌痛的老年人疼痛症状持续时间更长，这会对他们的生活质量产生负面影响。情感和神经炎症是可能加剧疼痛症状的潜在因素。运动是推荐的用于管理疼痛症状的干预措施；然而，依从性限制仍然存在。基于慢性疼痛的生物心理社会框架，本范围综述探讨运动如何影响与神经炎症和情感相关的因素，以及这些因素如何影响患有纤维肌痛的老年人的运动依从性。
我们对2024年之前发表的与运动和患有纤维肌痛的老年人相关的文章进行了范围检索。提取的研究特征包括发表类型、研究设计、情感结果、神经炎症结果、运动类型、运动依从性和样本人口统计学信息。
我们概述了在涉及患有纤维肌痛的老年人的研究中情感与神经炎症之间的关系，并强调了运动对患有纤维肌痛的老年人的情感和神经炎症的影响。提供了一个概念框架，说明了运动、情感变化、神经炎症和运动依从性之间的相互关系。
我们的结果表明运动可能改善情感，而有限的证据表明有氧运动和抗阻运动可改善神经炎症。最后，在潜在生物因素受到影响的背景下，阐述了其重要性及未来方向。
