用于现代疫苗开发的计算工具。
Computational tools for modern vaccine development.
机构信息
Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, India.
Bacterial Pathogenesis Laboratory, Department of Zoology, University of Delhi, Delhi.
出版信息
Hum Vaccin Immunother. 2020 Mar 3;16(3):723-735. doi: 10.1080/21645515.2019.1670035. Epub 2019 Dec 18.
Abstract
Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not only arrest the beginning of different diseases but also assign a gateway for its elimination and reduce toxicity. This review gives an overview of the possible uses of computational tools for vaccine design. Moreover, we have described the initiatives of utilizing the diverse computational resources by exploring the immunological databases for developing epitope-based vaccines, peptide-based drugs, and other resources of immunotherapeutics. Finally, the applications of multi-graft and multivalent scaffolding, codon optimization and antibodyomics tools in identifying and designing vaccine candidates are described.
摘要
疫苗在控制病死率和发病率方面发挥着重要作用。疫苗不仅可以阻止疾病的发生，还为疾病的消除开辟了道路，并降低了毒性。本综述概述了计算工具在疫苗设计中的可能应用。此外，我们还描述了利用各种计算资源的举措，通过探索免疫数据库来开发基于表位的疫苗、基于肽的药物和其他免疫治疗资源。最后，描述了多嵌合体和多价支架、密码子优化和抗体组学工具在鉴定和设计疫苗候选物方面的应用。
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