Biomaterials and Multiscale Mechanics Lab, Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, Roorkee 247667, India; Department of Mechanical Engineering, Madanapalle Institute of Technology & Science, Angallu, Madanapalle - 517325.
Tissue Engineering Lab, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110117. doi: 10.1016/j.msec.2019.110117. Epub 2019 Aug 23.
Failure of fixation between bone and implant surface due to bacterial infection, is one of the key challenges in total hip arthroplasty. It might lead to poor implant stability and complex revision surgery. Surface modification of an acetabular cup liner for sustained drug delivery is an effective approach to reduce the biofilms associated infection. The aim of the study is to evaluate the influence of different surface modification technique on drug delivery, mechanical and tribological performances of the acetabular cup liner. Solvent-based etching and electrostatic spray deposition technique was individually used to engineer a thin microporous surface layer on ultra-high molecular weight polyethylene (UHMWPE), which is commercially used as acetabular cup liner in total hip implant. Porous surfaces were filled with drug (gentamicin) containing biodegradable polymer (chitosan) through impregnation process and their efficacy was compared in the intended application. The surfaces, modified by both techniques, have shown lower friction coefficient. The higher wear rates were noticed for electrostatic sprayed coating. Both the modified surfaces have shown slight decrease in hardness and elastic modulus, which may be attributed to improper impregnation of polymer inside porous surface. However, after the release of drug, the solvent-based etched surface regains its mechanical and tribological properties, in similar range to the unmodified UHMWPE surface. Both the modified surfaces have shown an impressive drug release profile and in vitro antibacterial efficacy. The drug release duration was more for electrostatic spray modified surface. Hence, these surfaces modified implant parts shown great promise for fighting against post-surgery bacterial infection.
由于细菌感染导致骨与植入物表面固定失败，是全髋关节置换术的关键挑战之一。它可能导致植入物稳定性差和复杂的翻修手术。为了减少与生物膜相关的感染，对髋臼杯衬里进行持续药物输送的表面改性是一种有效的方法。本研究旨在评估不同表面改性技术对髋臼杯衬里的药物输送、机械和摩擦学性能的影响。分别使用基于溶剂的蚀刻和静电喷涂沉积技术在超高分子量聚乙烯（UHMWPE）上构建薄的微孔表面层，UHMWPE 商业上用作全髋关节植入物的髋臼杯衬里。通过浸渍工艺将多孔表面填充有药物（庆大霉素）和可生物降解聚合物（壳聚糖），并在预期应用中比较它们的效果。两种技术改性的表面都表现出较低的摩擦系数。静电喷涂涂层的磨损率较高。两种改性表面的硬度和弹性模量都略有下降，这可能归因于聚合物在多孔表面内的不当浸渍。然而，在释放药物后，基于溶剂的蚀刻表面恢复了其机械和摩擦学性能，与未改性的 UHMWPE 表面相似。两种改性表面都表现出令人印象深刻的药物释放曲线和体外抗菌效果。静电喷涂改性表面的药物释放持续时间更长。因此，这些改性植入物部件的表面在对抗手术后细菌感染方面显示出巨大的潜力。
