Manoj Kumar R, Gupta Pallavi, Sharma Sandan Kumar, Mittal Akshat, Shekhar Manish, Kumar Vijayesh, Manoj Kumar B V, Roy Partha, Lahiri Debrupa
Biomaterials and Multiscale Mechanics Lab, Indian Institute of Technology Roorkee, Roorkee 247667, India; Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Biomaterials and Multiscale Mechanics Lab, Indian Institute of Technology Roorkee, Roorkee 247667, India; Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:649-661. doi: 10.1016/j.msec.2017.03.221. Epub 2017 Mar 25.
Despite sterilization and aseptic procedure, bacterial infection remains a key challenge in total hip arthroplasties. This fact emphasizes the urgent need for development of new implant systems, which should releases the drug in a controlled manner without sparing its mechanical and tribological properties. In this study, the lining material of the acetabular cup, in total hip implant, has been modified for sustained release of drugs, which should be available throughout the site of implantation to fight the post-operation bacterial infection. A modified solvent based etching and lypolization technique has been used to engineer a thin porous surface layer on ultra-high molecular weight polyethylene (UHMWPE) substrate, which is clinically used as acetabular-cup lining. Gentamicin loaded chitosan solution has been impregnated into modified surface, which suitably gets released over a long period. The main challenge was to keep the mechanical and tribological behavior of this lining material unaffected after the modification. Modified surface offers reduction in friction coefficient and wear rate, by 26% and 19%, respectively, in comparison to UHMWPE, which is encouraging towards the intended application. Hardness and elastic modulus decreases slightly, by 27% and 20%, respectively, possibly due to improper impregnation of chitosan inside porous surface. However, after drug release, the modified surface regains the mechanical and tribological behavior similar to unmodified UHMWPE. Surface modified UHMWPE have shown an impressive release profile for drug up to 26days and released >94.11% of the total drug content. In vitro antibacterial tests have proven that the modified surface of UHMWPE can effectively release the drug and fight against infection. This surface engineered acetabular cup lining is a promising candidate in the area of drug eluting implant, which can bring a significant advancement to the functionality of commercially used orthopedic implants by providing inherent capacity for fighting infections in-vivo.
尽管采取了灭菌和无菌操作程序，但细菌感染仍是全髋关节置换术中的一项关键挑战。这一事实凸显了开发新型植入系统的迫切需求，这种系统应能以可控方式释放药物，同时不损害其机械和摩擦学性能。在本研究中，对全髋关节植入物中髋臼杯的衬里材料进行了改性，以实现药物的持续释放，药物应能在整个植入部位发挥作用，以对抗术后细菌感染。采用了一种改进的基于溶剂的蚀刻和冻干技术，在超高分子量聚乙烯（UHMWPE）基材上设计出一层薄的多孔表面层，该基材临床上用作髋臼杯衬里。负载庆大霉素的壳聚糖溶液已被浸渍到改性表面，可在较长时间内适当释放。主要挑战在于改性后要保持这种衬里材料的机械和摩擦学性能不受影响。与UHMWPE相比，改性表面的摩擦系数和磨损率分别降低了26%和19%，这对预期应用来说是令人鼓舞的。硬度和弹性模量分别略有下降，为27%和20%，这可能是由于壳聚糖在多孔表面内浸渍不当所致。然而，药物释放后，改性表面恢复了与未改性UHMWPE相似的机械和摩擦学性能。表面改性的UHMWPE在长达26天的时间内展现出令人印象深刻的药物释放曲线，释放了超过94.11%的总药物含量。体外抗菌测试证明，UHMWPE的改性表面能够有效释放药物并对抗感染。这种表面工程化的髋臼杯衬里是药物洗脱植入领域中一个很有前景的候选材料，通过提供体内抗感染的固有能力，可为商业使用的骨科植入物的功能带来重大进展。
