Department of Vitreo Retina, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Department of Paediatric Ophthalmology, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Indian J Ophthalmol. 2019 Oct;67(10):1768-1771. doi: 10.4103/ijo.IJO_2070_18.
To describe the optical coherence tomography (OCT) and electrophysiological changes in a case of closantel toxicity. A 25-year-old patient presented with sudden painless defective vision following intake of closantel. Visual acuity (VA) was counting fingers at 5 m in both eyes (BE). OCT revealed disruption of outer retinal layers and electroretinogram (ERG) and visual evoked potential (VEP) were subnormal in BE. The patient was treated with systemic corticosteroids, after which his VA improved to 6/9, OCT revealed preservation of central outer retinal layers, and ERG and VEP responses improved in BE. This is the first case report of successful treatment with systemic steroids for closantel-related reversible blindness.
描述一例氯硝柳胺中毒的光学相干断层扫描（OCT）和电生理变化。一名 25 岁患者在摄入氯硝柳胺后出现突发性无痛性视力丧失。双眼视力（VA）均为 5 米指数（BE）。OCT 显示外视网膜层中断，视网膜电图（ERG）和视觉诱发电位（VEP）在 BE 中均低于正常。患者接受全身皮质类固醇治疗后，VA 提高至 6/9，OCT 显示中央外视网膜层保存，ERG 和 VEP 反应在 BE 中改善。这是首例氯硝柳胺相关可逆性失明全身类固醇治疗成功的病例报告。
