Khandazhinskaya Anastasia L, Matyugina Elena S, Solyev Pavel N, Wilkinson Maggie, Buckheit Karen W, Buckheit Robert W, Chernousova Larisa N, Smirnova Tatiana G, Andreevskaya Sofya N, Alzahrani Khalid J, Natto Manal J, Kochetkov Sergey N, de Koning Harry P, Seley-Radtke Katherine L
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia.
ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA.
Molecules. 2019 Sep 21;24(19):3433. doi: 10.3390/molecules24193433.
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
碳环核苷长期以来在抗病毒、抗寄生虫和抗菌治疗中发挥着作用。我们实验室最近从两个结构相关的支架获得的结果显示，它们对[具体病毒名称缺失]和几种寄生虫菌株具有有前景的活性。因此，设计了一项小型构效关系研究，以进一步探究它们的活性和潜力。本文报道了它们的合成及后续生物活性结果。
