DNA甲基化与微小RNA：肝细胞癌早期诊断中最新且相关的生物标志物
DNA Methylation and Micro-RNAs: The Most Recent and Relevant Biomarkers in the Early Diagnosis of Hepatocellular Carcinoma.
作者信息
Cozma Angela, Fodor Adriana, Vulturar Romana, Sitar-Tăut Adela-Viviana, Orăşan Olga Hilda, Mureşan Flaviu, Login Cezar, Suharoschi Ramona
机构信息
Internal Medicine Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Diabetes and Metabolic Diseases, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
出版信息
Medicina (Kaunas). 2019 Sep 19;55(9):607. doi: 10.3390/medicina55090607.
Hepatocellular carcinoma (HCC) is a frequently encountered cancer type, and its alarming incidence is explained by genetic and epigenetic alterations. Epigenetic changes may represent diagnostic and prognostic biomarkers of HCC. In this review we discussed deoxyribonucleic acid (DNA) hypomethylation, DNA hypermethylation, and aberrant expression of small non-coding ribonucleic acid (RNA), which could be useful new biomarkers in the early diagnosis of HCC. We selected the articles on human subjects published in English over the past two years involving diagnostic markers detected in body fluids, cancer diagnosis made on histopathological exam, and a control group of those with benign liver disease or without liver disease. These biomarkers need further investigation in clinical trials to develop clinical applications for early diagnosis and management of HCC.
肝细胞癌（HCC）是一种常见的癌症类型，其惊人的发病率可由基因和表观遗传改变来解释。表观遗传变化可能代表HCC的诊断和预后生物标志物。在本综述中，我们讨论了脱氧核糖核酸（DNA）低甲基化、DNA高甲基化以及小非编码核糖核酸（RNA）的异常表达，这些可能是HCC早期诊断中有价值的新生物标志物。我们选择了过去两年以英文发表的关于人类受试者的文章，这些文章涉及在体液中检测到的诊断标志物、基于组织病理学检查做出的癌症诊断，以及一组患有良性肝病或无肝病的对照组。这些生物标志物需要在临床试验中进一步研究，以开发用于HCC早期诊断和管理的临床应用。
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