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本文引用的文献

1
Transgelin promotes migration and invasion of cancer stem cells.转胶蛋白促进癌症干细胞的迁移和侵袭。
J Proteome Res. 2010 Oct 1;9(10):5108-17. doi: 10.1021/pr100378z.
2
Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.肝癌中癌症干细胞的表观遗传调控：当前概念和临床意义。
J Hepatol. 2010 Sep;53(3):568-77. doi: 10.1016/j.jhep.2010.05.003. Epub 2010 May 31.
3
Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma.肝癌中肿瘤干细胞标志物的免疫组织化学染色。
Exp Mol Pathol. 2010 Aug;89(1):27-35. doi: 10.1016/j.yexmp.2010.05.005. Epub 2010 May 16.
4
DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC).溃疡性结肠炎患者结直肠黏膜中 ESR-1 和 N-33 的 DNA 甲基化。
Epigenetics. 2010 Jul 1;5(5):422-6. doi: 10.4161/epi.5.5.11959.
5
Advanced hepatocellular carcinoma: which staging systems best predict prognosis?晚期肝细胞癌：哪种分期系统能更好地预测预后？
J Clin Oncol. 2010 Jun 10;28(17):2889-95. doi: 10.1200/JCO.2009.25.9895. Epub 2010 May 10.
6
Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver.在啮齿动物和患病人类肝脏中对典型的细胞和细胞外成年肝祖细胞龛的特征描述。
Gut. 2010 May;59(5):645-54. doi: 10.1136/gut.2009.182345.
7
Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors.肝细胞癌表现出独特的 DNA 甲基化特征，具有作为临床预测指标的潜力。
PLoS One. 2010 Mar 17;5(3):e9749. doi: 10.1371/journal.pone.0009749.
8
High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma.高通量评估 CpG 位点甲基化，以区分 HCV 肝硬化和 HCV 相关肝细胞癌。
Mol Genet Genomics. 2010 Apr;283(4):341-9. doi: 10.1007/s00438-010-0522-y. Epub 2010 Feb 18.
9
Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer.免疫沉淀核小体 DNA 是一种提高结肠癌相关 p16 高甲基化血清筛选敏感性的新方法。
Cancer Epidemiol. 2010 Apr;34(2):194-9. doi: 10.1016/j.canep.2010.01.004. Epub 2010 Feb 2.
10
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.DNMT 及其表观遗传调控在肺癌治疗中的潜力。
Curr Genomics. 2009 Aug;10(5):336-52. doi: 10.2174/138920209788920994.

肝细胞癌中 DNA 甲基化的临床意义。

Clinical implications of DNA methylation in hepatocellular carcinoma.

机构信息

Department of Surgery, University of Texas Medical School at Houston, Houston, TX 77026, USA.

出版信息

HPB (Oxford). 2011 Jun;13(6):369-76. doi: 10.1111/j.1477-2574.2011.00303.x. Epub 2011 Mar 29.

DOI:10.1111/j.1477-2574.2011.00303.x
PMID:21609368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103092/
Abstract

BACKGROUND

Epigenetics is a rapidly evolving field of genetic study applicable to nearly every aspect of genome-related research. The importance of epigenetics has been recognised in human hepatocellular carcinoma (HCC). Changes in DNA methylation patterns, including global hypomethylation and promoter hypermethylation, are thought to be early events in hepatocarcinogenesis.

OBJECTIVES

This review aimed to summarise the role of epigenetics in HCC, to describe the mechanisms of epigenetic changes in HCC and to examine the clinical relevance of epigenetics in HCC.

METHODS

This review examines the role of CpG-rich regions and DNA methylation, and describes an epigenetic model of cancer, tumour type-specific methylation, the relationships among methylation, cirrhosis and hepatocarcinogenesis, and the role of DNA methylation in HCC. The clinical implications of epigenetics in HCC are discussed.

RESULTS

A multivariate predictor model based on traditional clinical factors and DNA methylation profile may have important applications in the early detection of neoplastic transformation in populations at high risk for HCC. CpG methylation may be valuable in HCC prognostics. DNA methylation profiles may enable clinical prediction in pre-therapy patient biopsies, paraffin-embedded samples or plasma DNA.

CONCLUSIONS

Epigenetic changes and profiles may correlate to the biological behaviour of tumours and clinical outcome of HCC patients. The use of DNA methylation profiles as a surrogate biomarker remains an active area of clinical cancer research.

摘要

背景

表观遗传学是遗传学研究的一个快速发展的领域，几乎适用于与基因组相关的研究的各个方面。表观遗传学在人类肝细胞癌（HCC）中具有重要意义。DNA 甲基化模式的变化，包括全局低甲基化和启动子高甲基化，被认为是肝癌发生的早期事件。

目的

本综述旨在总结表观遗传学在 HCC 中的作用，描述 HCC 中表观遗传变化的机制，并研究表观遗传学在 HCC 中的临床相关性。

方法

本综述检查了富含 CpG 区域和 DNA 甲基化的作用，并描述了癌症的表观遗传模型、肿瘤类型特异性甲基化、甲基化、肝硬化和肝癌发生之间的关系，以及 DNA 甲基化在 HCC 中的作用。讨论了表观遗传学在 HCC 中的临床意义。

结果

基于传统临床因素和 DNA 甲基化谱的多变量预测模型可能在高危 HCC 人群中肿瘤转化的早期检测中具有重要应用。CpG 甲基化在 HCC 预后中有价值。DNA 甲基化谱可用于预测治疗前患者活检、石蜡包埋样本或血浆 DNA。

结论

表观遗传变化和特征可能与肿瘤的生物学行为和 HCC 患者的临床结果相关。将 DNA 甲基化谱用作替代生物标志物的方法仍然是临床癌症研究的活跃领域。