Facal David, Guàrdia-Olmos Joan, Pereiro Arturo X, Lojo-Seoane Cristina, Peró Maribel, Juncos-Rabadán Onésimo
Department of Developmental Psychology, University de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain.
Department of Methodology of Behavioural Sciences, University of Barcelona, 08035 Barcelona, Catalunya, Spain.
Brain Sci. 2019 Sep 19;9(9):242. doi: 10.3390/brainsci9090242.
(1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9-15 months-sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27-33-sda-MCI OR = 16 and mda-MCI = 5.06; interval 42-48-sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45-51-sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed.
(1) 背景：轻度认知障碍（MCI）是一种诊断标签，其稳定性通常较低。本研究的目的是采用重叠时间策略来研究MCI亚型诊断的时间变化；(2) 方法：该研究纳入了435名年龄超过50岁、有主观认知主诉且至少完成了一次随访评估的参与者。使用贝叶斯优势比估计转变概率；(3) 结果：在不同的时间间隔内，有主观认知主诉的对照组参与者占比最大，其次是基线时以及随访的前五个时间间隔内的单一领域MCI（sda-MCI），但在最后八个时间间隔内并非如此。优势比表明，相对于非遗忘型MCI（na-MCI），sda-MCI组和多领域MCI（mda-MCI）组转变为痴呆症的可能性更高（例如，9 - 15个月时间间隔 - sda-MCI的优势比 = 9，mda-MCI的优势比 = 3.36；27 - 33时间间隔 - sda-MCI的优势比 = 16，mda-MCI的优势比 = 5.06；42 - 48时间间隔 - sda-MCI的优势比 = 8.16，mda-MCI的优势比 = 3.45；45 - 51时间间隔 - sda-MCI的优势比 = 3.31，mda-MCI的优势比 = 1）；(4) 结论：观察到了与当前文献一致的显著不稳定性模式。讨论了前瞻性方法在MCI转变研究中的局限性。
