Cardiology Department, Mother and Child Health Care Institute of Serbia "Dr.Vukan Cupic", 11070 Belgrade, Serbia.
School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Medicina (Kaunas). 2019 Sep 20;55(10):609. doi: 10.3390/medicina55100609.
: Recurrence of pericarditis (ROP) is an important complication of the acute pericarditis. The aim of this study was to analyse the influence of aetiology, clinical findings and treatment on the outcome of acute pericarditis. : Data were retrospectively collected from medical records of patients treated from 2011 to 2019 at a tertiary referent heart paediatric center. : Our investigation included 56 children with idiopathic and viral pericarditis. Relapse was registered in 8/56 patients, 2/29 (7.41%) treated with nonsteroidal anti-inflammatory drugs (NSAID) and 6/27 (28.57%) treated with corticosteroids (CS) and NSAID. Independent risk factors for ROP were viral pericarditis ( = 0.01, OR 31.46), lack of myocardial affection ( = 0.03, OR 29.15), CS use ( = 0.02, OR 29.02) and ESR ≥ 50 mm/h ( = 0.03, OR 25.23). In 4/8 patients the first recurrence was treated with NSAID and colchicine, while treatment of 4/8 patients included CS. Children with ROP treated with CS had higher median number of recurrence (5, IQR: 2-15) than those treated with colchicine (0, IQR: 0-0.75). : Independent risk factors for recurrence are CS treatment, viral aetiology, pericarditis only and ESR ≥ 50 mm/h. Acute pericarditis should be treated with NSAID. Colchicine and NSAID might be recommended in children with the first ROP.
: 复发性心包炎（ROP）是急性心包炎的一个重要并发症。本研究旨在分析病因、临床特征和治疗对急性心包炎结局的影响。 : 数据从 2011 年至 2019 年在一家三级心脏儿科中心接受治疗的患者的病历中回顾性收集。 : 我们的研究包括 56 例特发性和病毒性心包炎患儿。56 例患者中有 8 例（7.41%）复发，其中 29 例（28.57%）接受非甾体抗炎药（NSAID）治疗，27 例（28.57%）接受皮质类固醇（CS）和 NSAID 治疗。ROP 的独立危险因素包括病毒性心包炎（ = 0.01，OR 31.46）、无心肌受累（ = 0.03，OR 29.15）、CS 应用（ = 0.02，OR 29.02）和 ESR ≥ 50 mm/h（ = 0.03，OR 25.23）。8 例患者中有 4 例首次复发采用 NSAID 和秋水仙碱治疗，而 4 例患者采用 CS 治疗。接受 CS 治疗的 ROP 患儿的中位复发次数（5，IQR：2-15）高于接受秋水仙碱治疗的患儿（0，IQR：0-0.75）。 : 复发的独立危险因素是 CS 治疗、病毒病因、单纯心包炎和 ESR ≥ 50 mm/h。急性心包炎应采用 NSAID 治疗。对于首次发生 ROP 的患儿，推荐使用秋水仙碱和 NSAID。
