Culling W, Ruttley M S, Sheridan D J
Br Heart J. 1984 Oct;52(4):431-4. doi: 10.1136/hrt.52.4.431.
The acute effects of felodipine on left ventricular function and haemodynamics were studied in 11 patients with coronary artery disease. To block reflex sympathetic activation due to peripheral vasodilatation and to avoid effects secondary to changes in heart rate all patients received a standard regimen of beta adrenoceptor blockade and all measurements were made during sinus rhythm and right atrial pacing. At 30 minutes after an oral dose (0.075 mg/kg in solution) felodipine plasma concentration were 16.4 (3.5) nmol/l. A significant fall in systemic vascular resistance (30%) and increase in cardiac index (30%) occurred, whereas pulmonary vascular resistance was unchanged. Felodipine increased left ventricular ejection fraction and mean velocity of circumferential fibre shortening but had no effect on derivates of left ventricular pressure (dP/dt or dP/dt P-1) during sinus rhythm or pacing. Thus at the dosage used felodipine was a potent dilator of systemic arterioles but had no direct effect on left ventricular function.
在11例冠心病患者中研究了非洛地平对左心室功能和血流动力学的急性影响。为阻断因外周血管扩张引起的反射性交感神经激活并避免心率变化的继发效应，所有患者均接受标准的β肾上腺素能受体阻滞剂治疗方案，且所有测量均在窦性心律和右心房起搏期间进行。口服剂量（溶液中0.075mg/kg）后30分钟，非洛地平血浆浓度为16.4（3.5）nmol/l。全身血管阻力显著下降（30%），心脏指数增加（30%），而肺血管阻力未改变。非洛地平增加了左心室射血分数和圆周纤维缩短平均速度，但在窦性心律或起搏期间对左心室压力导数（dP/dt或dP/dt P-1）无影响。因此，在所使用的剂量下，非洛地平是一种强效的全身小动脉扩张剂，但对左心室功能无直接影响。
