Leon-Sarmiento Fidias E, Gonzalez-Castaño Alexander, Rizzo-Sierra Carlos V, Aceros Juan, Leon-Ariza Daniel S, Leon-Ariza Juan S, Prada Diddier G, Bara-Jimenez William, Wang Zeng Y
Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA.
Research (Wash D C). 2019 Mar 26;2019:7109535. doi: 10.34133/2019/7109535. eCollection 2019.
The content of the rectified motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) has ambiguously been assessed without the precision that energy calculation deserves. This fact has misled data interpretation and misguided biomedical interventions. To definitively fill the gap that exits in the neurophysics processing of these signals, we computed, in the within the rectified MEP recorded from the human first digitorum index (FDI) muscle at rest and under isometric contraction. We also gauged the exerted by this muscle. Here we show that bioenergy and biowork can accurately and successfully be assessed, validated, and determined in from MEP signals induced by TMS, regardless of knowing the mathematical expression of the function of the signal. Our novel neurophysics approach represents a dramatic paradigm shift in analysis and interpretation of the content of the MEP and will give a true meaning to the content of rectified signals. Importantly, this innovative approach allowed unveiling that women exerted more bioenergy than men at the magnetic stimulations used in this study. Revisitation of conclusions drawn from studies published elsewhere assessing rectified EMG signals that have used ambiguous units is strongly recommended.
经颅磁刺激（TMS）诱发的整流运动诱发电位（MEP）的内容评估一直不够明确，缺乏能量计算应有的精确性。这一事实误导了数据解读，并导致生物医学干预出现偏差。为了彻底填补这些信号在神经物理学处理方面存在的空白，我们对静息和等长收缩状态下从人类示指（FDI）肌肉记录的整流MEP进行了计算。我们还测量了该肌肉所施加的力。在这里，我们表明，无论是否知道信号函数的数学表达式，都可以从TMS诱发的MEP信号中准确、成功地评估、验证和确定生物能量和生物功。我们新颖的神经物理学方法代表了MEP内容分析和解读方面的重大范式转变，并将赋予整流信号内容真正的意义。重要的是，这种创新方法揭示了在本研究中使用的磁刺激下，女性比男性消耗更多的生物能量。强烈建议重新审视其他地方发表的使用模糊单位评估整流肌电图信号的研究得出的结论。
