From the Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Que. (Carrier); and the Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Que. (Giraldeau, Parent, Ducharme).
Can J Surg. 2019 Oct 1;62(5):356-357. doi: 10.1503/cjs.011018.
Cardiac toxicity from recreational drug use remains difficult to establish. We report the cases of 3 young patients who were hospitalized for cardiogenic shock. All were bridged to transplantation with implantation of a left ventricular assist device (LVAD). They underwent uneventful heart transplantation. The patients did not have any significant personal or family medical history, but all admitted consuming large quantities of recreational drugs daily. Histological examination of the native heart did not show any inflammation or infiltrative myocardial disease. In this series of young patients presenting in cardiogenic shock with minimal histologic findings on examination of the native hearts, the association between cardiac toxicity and active use of recreational drugs remains a strong possibility. The transplant community should be made aware of this possible association in the current era of legalization and social trivialization of drug consumption.
因消遣性药物使用而导致的心脏毒性仍然难以确定。我们报告了 3 例因心源性休克而住院的年轻患者的病例。所有患者均通过植入左心室辅助装置（LVAD）成功过渡到移植。他们随后进行了心脏移植手术，过程均顺利。这些患者没有任何显著的个人或家族病史，但均承认每天大量使用消遣性药物。对原生心脏的组织学检查并未显示任何炎症或浸润性心肌疾病。在这一系列年轻患者中，他们因心源性休克而出现心脏毒性，而原生心脏的检查结果几乎没有组织学发现，这表明心脏毒性与消遣性药物的使用之间存在很强的关联性。在当前药物使用合法化和社会淡化的时代，移植界应该意识到这种可能的关联。
