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老年人复杂轻度创伤性脑损伤:伤后一周的脑震荡后症状及功能结局

Complicated mild traumatic brain injury in older adults: Post-concussion symptoms and functional outcome at one week post injury.

作者信息

Karr Justin E, Iverson Grant L, Berghem Ksenia, Kotilainen Anna-Kerttu, Terry Douglas P, Luoto Teemu M

机构信息

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.

Spaulding Rehabilitation Hospital, Boston, MA, USA.

出版信息

Brain Inj. 2020;34(1):26-33. doi: 10.1080/02699052.2019.1669825. Epub 2019 Sep 24.

Abstract

Mild Traumatic Brain Injury (MTBI) is commonly categorized as when injury severity criteria are mild, but an intracranial abnormality is present on acute neuroimaging. The current study examined whether functional outcomes differed at one week post injury among older adult patients based on injury severity and acute computed tomography (CT) findings. Participants (≥55 years-old; = 173) presenting sequentially to the emergency department with a head injury were divided into three groups: complicated MTBI (positive CT; = 22), uncomplicated MTBI (negative CT; = 68), and mild head injury (unperformed CT, no documented loss of consciousness or post-traumatic amnesia; = 83). At one week post injury, the Modified Rankin Scale (i.e., difference score between pre/post-injury ratings; ∆MRS), Glasgow Outcome Scale-Extended (GOS-E), and Rivermead Post-Concussion Symptoms Questionnaire (RPQ) were administered. Participants differed on the ∆MRS and GOS-E, but not the RPQ. The complicated MTBI group had worse GOS-E ratings than the uncomplicated MTBI and mild head injury groups and worse ∆MRS than the mild head injury group, but the uncomplicated MTBI and mild head injury groups did not differ on either outcome. Macrostructural abnormality on CT was associated with worse functional outcome at one week post MTBI.

摘要

轻度创伤性脑损伤(MTBI)通常被归类为损伤严重程度标准为轻度,但急性神经影像学检查发现颅内存在异常的情况。本研究调查了老年成年患者在受伤一周后,根据损伤严重程度和急性计算机断层扫描(CT)结果,功能结局是否存在差异。依次到急诊科就诊的头部受伤患者(≥55岁;n = 173)被分为三组:复杂性MTBI(CT阳性;n = 22)、非复杂性MTBI(CT阴性;n = 68)和轻度头部损伤(未进行CT检查,无记录的意识丧失或创伤后遗忘;n = 83)。在受伤一周后,使用改良Rankin量表(即受伤前后评分的差异得分;∆MRS)、格拉斯哥扩展预后量表(GOS-E)和Rivermead脑震荡后症状问卷(RPQ)进行评估。参与者在∆MRS和GOS-E上存在差异,但在RPQ上没有差异。复杂性MTBI组的GOS-E评分比非复杂性MTBI组和轻度头部损伤组差,∆MRS比轻度头部损伤组差,但非复杂性MTBI组和轻度头部损伤组在这两个结局上没有差异。MTBI后一周,CT上的宏观结构异常与较差的功能结局相关。

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