Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, University Avenue, Toronto, ON, M5G 1X8, Canada.
Section of Neonatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
J Perinatol. 2020 Jan;40(1):39-45. doi: 10.1038/s41372-019-0497-4. Epub 2019 Sep 24.
To study the effect of early and late onset preeclampsia (EOPE, LOPE, respectively) on outcomes of late preterm infants.
Cohort study of late preterm infants admitted to a tertiary care NICU from January 2014-July 2015. Outcomes of late preterm infants of EOPE mothers were compared with the next late preterm infant of a LOPE mother and the next two late preterm infants of normotensive non-PE mothers. Primary outcome comprised use of continuous positive airway pressure, mechanical ventilation and/or surfactant in the 24 h after birth.
Compared to normotensives (n = 131), adjusted odds ratio (AORs) of the primary outcome was higher in the EOPE (n = 64) and LOPE (n = 65) groups but reached statistical significance only in the EOPE group, AORs 12.9, 95% CI 3.5-37 and 2.7, 95% CI 0.95-8.1, respectively.
Compared to late preterm infants of normotensive and LOPE mothers, infants of mothers with EOPE have significantly higher respiratory morbidity.
研究早发型和晚发型子痫前期（EOPE、LOPE）对晚期早产儿结局的影响。
对 2014 年 1 月至 2015 年 7 月在一家三级护理 NICU 住院的晚期早产儿进行队列研究。将 EOPE 母亲的晚期早产儿的结局与 LOPE 母亲的下一个晚期早产儿和血压正常非 PE 母亲的下两个晚期早产儿进行比较。主要结局包括出生后 24 小时内使用持续气道正压通气、机械通气和/或表面活性剂。
与血压正常者（n=131）相比，EOPE（n=64）和 LOPE（n=65）组的主要结局的校正比值比（AORs）较高，但仅在 EOPE 组达到统计学意义，AORs 分别为 12.9、95%CI3.5-37 和 2.7、95%CI0.95-8.1。
与血压正常和 LOPE 母亲的晚期早产儿相比，EOPE 母亲的婴儿呼吸发病率明显更高。
