Discordant interleukin 2 production in monozygotic twins concordant for systemic lupus erythematosus.
作者信息
Sato K, Miyasaka N, Yamaoka K, Yamada T, Nishido T, Okuda M, Nishioka K
机构信息
Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
出版信息
Autoimmunity. 1988;2(1):3-9. doi: 10.3109/08916938809019938.
PMID:3155152
Abstract
We present data from monozygotic twins concordant for SLE. IL-2 production by peripheral blood mononuclear cells from the patients, when they were discordant for SLE activity, were measured employing cellular mixing experiments. Macrophages from active SLE had a suppressive effect on IL-2 production. Furthermore, SLE T cells appeared to have a defect in IL-2 production irrespective of disease activity. These defects might play an important role in the disordered immunoregulation in SLE.
摘要
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