常见的脑部疾病与大脑明显衰老的遗传模式有关。
Common brain disorders are associated with heritable patterns of apparent aging of the brain.
机构信息
NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
School of Mental Health and Neuroscience Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
出版信息
Nat Neurosci. 2019 Oct;22(10):1617-1623. doi: 10.1038/s41593-019-0471-7. Epub 2019 Sep 24.
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
常见的精神和其他脑部疾病的风险因素可能集中在影响大脑结构和功能在整个生命周期中发展和维持的生物途径上。利用来自 3 至 96 岁 45615 人的结构磁共振成像数据，我们在几种脑部疾病中证明了明显的大脑衰老模式，并揭示了健康个体的表观大脑衰老与常见脑部疾病之间的遗传多效性。
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