Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
World J Biol Psychiatry. 2020 Dec;21(10):748-756. doi: 10.1080/15622975.2019.1671610. Epub 2019 Oct 4.
Ghrelin, an orexigenic peptide hormone, promotes drug reward and is suspected to play a role in nicotine dependence. However, there is little data on whether ghrelin levels are associated with active and/or former smoking. The relationship between ghrelin serum levels and smoking status in a population-based sample of individuals was studied.
Total ghrelin was determined after an overnight fast in 1519 subjects participating in a population-based cohort study ('LIFE-Adult'). Tobacco consumption was assessed using both the questionnaire and interview. Generalised linear models with gamma distribution and log-link function were performed to analyse the association of total serum ghrelin with smoking status and the association between serum ghrelin and the amount of tobacco consumed in active smokers.
Ghrelin levels were positively associated with active, but not former smoking (OR = 1.095; = .002). This association was not moderated by sex (interaction of 'active smoking' and sex: = .346). Ghrelin levels were not associated with the amount of tobacco consumed in active smokers.
This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size.
Ghrelin 是一种食欲肽激素，它能促进药物奖赏，并被怀疑在尼古丁依赖中发挥作用。然而，关于 ghrelin 水平是否与主动和/或曾经吸烟有关的数据很少。本研究旨在研究人群中 ghrelin 血清水平与吸烟状况之间的关系。
在一项基于人群的队列研究（LIFE-Adult）中，1519 名参与者在禁食一夜后测定总 ghrelin。使用问卷和访谈评估烟草消费。采用具有伽马分布和对数链接函数的广义线性模型来分析总血清 ghrelin 与吸烟状况的关系，以及血清 ghrelin 与主动吸烟者吸烟量之间的关系。
Ghrelin 水平与主动吸烟呈正相关，但与既往吸烟无关（OR=1.095；P=0.002）。这种关联不受性别调节（“主动吸烟”和性别的交互作用：P=0.346）。Ghrelin 水平与主动吸烟者吸烟量无关。
本研究提供了证据表明，总 ghrelin 血清水平与主动吸烟呈正相关。而在既往吸烟者中未发现这种关联。本研究的一个独特特征是样本量大。
