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False-negative Chlamydia polymerase chain reaction result caused by a cryptic plasmid-deficient Chlamydia trachomatis strain in Australia.澳大利亚一株隐匿性质粒缺陷型沙眼衣原体菌株导致衣原体聚合酶链反应结果假阴性
Sex Health. 2019 Aug;16(4):394-396. doi: 10.1071/SH18205.
2
Finnish new variant of escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019.芬兰变异株在 Aptima Combo 2 检测中也可被检出，该变异株亦存在于 2019 年 5 月瑞典于默奥省。
Euro Surveill. 2019 Jun;24(26). doi: 10.2807/1560-7917.ES.2019.24.26.1900370.
3
Letter to the editor: samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.致编辑的信：2019年芬兰Aptima Combo 2检测中出现假阴性结果的样本
Euro Surveill. 2019 Jun;24(24). doi: 10.2807/1560-7917.ES.2019.24.24.1900354.
4
samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.2019 年芬兰 Aptima Combo 2 检测中出现假阴性的样本。
Euro Surveill. 2019 May;24(22). doi: 10.2807/1560-7917.ES.2019.24.22.1900298.
5
Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae.雅培实时 CT/NG 在检测沙眼衣原体和淋病奈瑟菌中的性能。
J Clin Microbiol. 2010 Sep;48(9):3236-43. doi: 10.1128/JCM.01019-10. Epub 2010 Jul 28.
6
Emergence and spread of Chlamydia trachomatis variant, Sweden.沙眼衣原体变种在瑞典的出现与传播
Emerg Infect Dis. 2008 Sep;14(9):1462-5. doi: 10.3201/eid1409.080153.
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Monitoring the potential introduction of the Swedish Chlamydia trachomatis variant (swCT) in the Netherlands.监测瑞典沙眼衣原体变种（swCT）在荷兰可能的传入情况。
Euro Surveill. 2007 Oct 1;12(10):E9-E10. doi: 10.2807/esm.12.10.00739-en.
8
Results of a Europe-wide investigation to assess the presence of a new variant of Chlamydia trachomatis.一项全欧洲范围的调查结果，该调查旨在评估沙眼衣原体新变种的存在情况。
Euro Surveill. 2007 Oct 1;12(10):E3-4.
9
French situation concerning the Swedish Chlamydia trachomatis variant.法国关于瑞典沙眼衣原体变种的情况。
Euro Surveill. 2007 Oct 1;12(10):E11-2. doi: 10.2807/esm.12.10.00740-en.
10
Impact of a genetic variant of Chlamydia trachomatis on national detection rates in Sweden.沙眼衣原体基因变异对瑞典全国检测率的影响。
Euro Surveill. 2006 Dec 7;11(12):E061207.1. doi: 10.2807/esw.11.49.03090-en.

2019 年 6 月至 8 月，英国经 Aptima Combo 2 检测逃避检测的新变异株的流行率。

Prevalence of new variants of escaping detection by the Aptima Combo 2 assay, England, June to August 2019.

机构信息

National Infection Service, Public Health England, London, United Kingdom.

South West Regional Public Health Laboratory, Public Health England, Bristol, United Kingdom.

出版信息

Euro Surveill. 2019 Sep;24(38). doi: 10.2807/1560-7917.ES.2019.24.38.1900557.

DOI:10.2807/1560-7917.ES.2019.24.38.1900557
PMID:31552817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6761577/
Abstract

We identified two new (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

摘要

我们在两名患者的临床标本中发现了两种新的（CT）变体，能够逃避 Aptima Combo 2（AC2）检测。一种有 C1514T 突变，另一种有 G1523A 突变，均位于 AC2 23S rRNA 靶区域内。在英国接受 CT 检测的人群中，此类变体的流行率估计不到 0.003%。