Wang Shuo, Zhu Shi-Jie, Zhang Xue-Qi, Li Jing-An, Guan Shao-Kang
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou, Henan Province, China.
Med Gas Res. 2019 Jul-Sep;9(3):153-159. doi: 10.4103/2045-9912.266991.
Nitric oxide (NO) released by vascular endothelial cells (VECs), as a functional factor and signal pathway molecule, plays an important role in regulating vasodilation, inhibiting thrombosis, proliferation and inflammation. Therefore, numerous researches have reported the relationship between the NO level in VECs and the cardiovascular biomaterials' structure/functions. In recent years, biomedical magnesium (Mg) alloys have been widely studied and rapidly developed in the cardiovascular stent field for their biodegradable absorption property. However, influence of the Mg alloys' degradation products on VEC NO release is still unclear. In this work, Mg-Zn-Y-Nd, an Mg alloy widely applied on the biodegradable stent research, was investigated on the influence of the degradation time, the concentration and reaction time of degradation products on VEC NO release. The data showed that the degradation product concentration and the reaction time of degradation products had positive correlation with NO release, and the degradation time had negative correlation with NO release. All these influencing factors were controlled by the Mg alloy degradation behaviors. It was anticipated that it might make sense for the cardiovascular Mg alloy design aiming at VEC NO release and therapy.
血管内皮细胞（VECs）释放的一氧化氮（NO）作为一种功能因子和信号通路分子，在调节血管舒张、抑制血栓形成、增殖和炎症方面发挥着重要作用。因此，众多研究报道了VECs中NO水平与心血管生物材料的结构/功能之间的关系。近年来，生物医学镁（Mg）合金因其可生物降解吸收特性，在心血管支架领域得到了广泛研究并迅速发展。然而，Mg合金降解产物对VECs释放NO的影响仍不清楚。在这项工作中，研究了广泛应用于可生物降解支架研究的Mg合金Mg-Zn-Y-Nd的降解时间、降解产物浓度和反应时间对VECs释放NO的影响。数据表明，降解产物浓度和降解产物反应时间与NO释放呈正相关，而降解时间与NO释放呈负相关。所有这些影响因素都受Mg合金降解行为的控制。预计针对VECs释放NO和治疗的心血管Mg合金设计可能具有重要意义。
