School of Materials Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou, 450001, China.
J Mater Sci Mater Med. 2021 Apr 6;32(4):43. doi: 10.1007/s10856-021-06516-8.
Implant therapy after osteosarcoma surgery is a major clinical challenge currently, especially the requirements for mechanical properties, degradability of the implants, and their inhibition of residual tumor cells. Biodegradable magnesium (Mg) alloy as medical bone implant material has full advantages and huge potential development space. Wherein, Mg-lithium (Li) based alloy, as an ultra-light alloy, has good properties for implants under certain conditions, and both Mg and Li have inhibitory effects on tumor cells. Therefore, Mg-Li alloy is expected to be applied in bone implant materials for mechanical supporting and inhibiting tumor cells simultaneously. In this contribution, the Mg-xLi-Zinc (Zn) series alloys (x = 3 wt%, 6 wt%, 9 wt%) were prepared to study the influence of different elements and contents on the structure and properties of the alloy, and the biosafety of the alloy was also evaluated. Our data showed that the yield strength, tensile strength, and elongation of as-cast Mg-xLi-Zn alloy were higher than those of as-cast Mg-Zn alloy; Mg-xLi-Zn alloy can kill osteosarcoma cells (MG-63) in a concentration-dependent manner, wherein Mg-3Li-Zn alloy (x = 3 wt%) and Mg-6Li-Zn alloy (x = 6 wt%) promoted the proliferation of osteoblasts (MC3T3) at a certain concentration of Li. In summary, our study demonstrated that the Mg-6Li-Zn alloy could be potentially applied as a material of orthopedic implant for its excellent multi-functions.
骨肉瘤术后的种植体治疗目前是一个主要的临床挑战，特别是对植入物的机械性能、可降解性及其对残留肿瘤细胞的抑制作用的要求。可生物降解的镁（Mg）合金作为医用骨植入材料具有充分的优势和巨大的潜在发展空间。其中，Mg-锂（Li）基合金作为一种超轻合金，在某些条件下具有良好的植入物性能，且 Mg 和 Li 对肿瘤细胞均具有抑制作用。因此，Mg-Li 合金有望同时应用于机械支撑和抑制肿瘤细胞的骨植入材料中。在本研究中，制备了 Mg-xLi-锌（Zn）系列合金（x = 3 wt%、6 wt%、9 wt%），研究了不同元素和含量对合金结构和性能的影响，并评价了合金的生物安全性。我们的数据表明，铸态 Mg-xLi-Zn 合金的屈服强度、拉伸强度和伸长率均高于铸态 Mg-Zn 合金；Mg-xLi-Zn 合金能以浓度依赖的方式杀伤骨肉瘤细胞（MG-63），其中 Mg-3Li-Zn 合金（x = 3 wt%）和 Mg-6Li-Zn 合金（x = 6 wt%）在一定浓度的 Li 作用下能促进成骨细胞（MC3T3）的增殖。总之，我们的研究表明，Mg-6Li-Zn 合金可能具有作为骨科植入物材料的应用潜力，因其具有多种优良的功能。
