Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Xi'an Jiao Tong University, Xi'an, 710049, China.
Macromol Rapid Commun. 2019 Nov;40(22):e1900441. doi: 10.1002/marc.201900441. Epub 2019 Sep 25.
Finely tuning the photodegradation behavior of the layer-by-layer (LbL) film from the view of controlling the chemical structure of the film-building polymer is still a challenge in related fields. To meet this requirement, a photodegradable polymer (P1) is rationally designed for assembling a visible-light-degradable multilayer film with polystyrene sulfonate (PSS). Compared with similar photopolymers (P2 and P3), this asymmetric picolinium-containing polymer can significantly enhance the degradation rate of as-prepared LbL films; under the same degradation condition, the degradation rate of (P1/PSS)10 is 3 and 6.6 times that of (P2/PSS)10 and (P3/PSS)10, respectively. Moreover, near-infrared light (NIR) is available for triggering the degradation of this film with the assistance of upconversion nanoparticles of YbTm@Lu. The cell cytotoxicity and cell proliferation experiments reveal that P1 is nontoxic and favorable for cell proliferation at concentrations of up to 500 μg mL . As for (PSS/P1)10 films, the ratio of cell number of these two samples ((PSS/P1)10 modified: photodegraded) increases dramatically and reaches about 1.67:1 after 72 h incubation. On the basis of these results, it is anticipated that P1 and this LbL film is an exceptional candidate for visible-light/NIR degradable materials in materials and biological science, medicine, and optics.
从控制膜构筑聚合物化学结构的角度出发，精细调整层层（LbL）膜的光降解行为仍然是相关领域的一个挑战。为了满足这一要求，合理设计了一种可光降解的聚合物（P1），用于与聚苯乙烯磺酸盐（PSS）组装可见光降解的多层膜。与类似的光聚合体（P2 和 P3）相比，这种不对称的含吡啶鎓聚合物可以显著提高所制备的 LbL 膜的降解速率；在相同的降解条件下，（P1/PSS）10 的降解速率分别是（P2/PSS）10 和（P3/PSS）10 的 3 倍和 6.6 倍。此外，在上转换纳米粒子 YbTm@Lu 的辅助下，近红外光（NIR）可用于触发该膜的降解。细胞毒性和细胞增殖实验表明，P1 在高达 500μg mL 的浓度下无毒性且有利于细胞增殖。对于（PSS/P1）10 膜，这两种样品的细胞数量比（（PSS/P1）10 修饰：光降解）急剧增加，在孵育 72 小时后达到约 1.67:1。基于这些结果，可以预期 P1 和这种 LbL 膜是材料科学、医学和光学领域中可见光/NIR 可降解材料的理想候选材料。
