Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, Florida, USA,
Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, Florida, USA.
Cardiorenal Med. 2019;9(6):344-353. doi: 10.1159/000502438. Epub 2019 Sep 25.
There is limited evidence examining the relationship between elevated serum uric acid (sUA) concentration and heart failure (HF) in United States (US) adults. The aim of the present study was to examine the association(s) between elevated sUA and HF using a nationally representative sample of US adults.
The final sample with complete data for this analysis (n = 17,349) included men and women aged ≥40 years who participated in the 2007-2016 National Health and Nutrition Examination Survey. Self-reported diagnosis of HF was assessed via interview. Elevated sUA was defined as values >6.0 mg/dL for women and >7.2 mg/dL for men. Multivariable gender-stratified logistic regression was utilized to examine the odds of self-reported HF.
The estimated prevalence of HF was 3.9 and 3.4% among men and women, respectively. Age-adjusted analysis revealed significantly increased odds of HF in men (OR 2.79; 95% CI 2.15-3.84, p < 0.01) and women (OR 3.24; 95% CI 2.37-4.44, p < 0.01) with elevated sUA. This relationship remained statistically significant following adjustment for age, race, education, income, alcohol consumption, smoking status, blood pressure, diabetes, physical activity level, cholesterol, creatinine level, and body mass index in men (OR 1.70; 95% CI 1.13-2.57 p < 0.05) and women (OR 1.74; 95% CI 1.18-2.58, p < 0.05).
In a representative sample of US adults, having an elevated sUA concentration was associated with significantly increased odds of HF when compared to adults with normal sUA.
在美国成年人中，有关血清尿酸（sUA）浓度升高与心力衰竭（HF）之间关系的证据有限。本研究旨在使用具有代表性的美国成年人样本，研究升高的 sUA 与 HF 之间的关联。
本分析的最终完整数据集（n = 17349）包括年龄≥40 岁的男性和女性，他们参加了 2007-2016 年全国健康和营养检查调查。HF 的自我报告诊断通过访谈进行评估。升高的 sUA 定义为女性> 6.0mg/dL 和男性> 7.2mg/dL。采用多变量性别分层逻辑回归分析评估自我报告 HF 的比值比（OR）。
男性和女性的 HF 估计患病率分别为 3.9%和 3.4%。年龄调整分析显示，sUA 升高的男性（OR 2.79；95%CI 2.15-3.84，p < 0.01）和女性（OR 3.24；95%CI 2.37-4.44，p < 0.01）患 HF 的几率显著增加。在男性（OR 1.70；95%CI 1.13-2.57，p < 0.05）和女性（OR 1.74；95%CI 1.18-2.58，p < 0.05）中，调整年龄、种族、教育程度、收入、饮酒量、吸烟状况、血压、糖尿病、体力活动水平、胆固醇、肌酐水平和体重指数后，这种关系仍然具有统计学意义。
在具有代表性的美国成年人样本中，与 sUA 正常的成年人相比，sUA 浓度升高与 HF 的几率显著增加相关。
