Hospital of Stomatology, Jilin University, Changchun, Jilin Province, 130000, China.
BMC Oral Health. 2023 Aug 30;23(1):610. doi: 10.1186/s12903-023-03320-4.
Diabetes and other metabolic diseases have been linked to the development of periodontitis, but little research has been done to determine whether serum uric acid (SUA) levels and hyperuricemia play a role. This study aimed to investigate the relationship between SUA, hyperuricemia, and periodontitis.
Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, we created a nationally representative data set. We used multivariable logistic regression models to assess the relationship between SUA, hyperuricemia, and periodontitis and presented odds ratios (OR) in women and men, respectively.
In women, adjusted multivariable regression models showed that SUA (4.1-4.3mg/dl) was associated with higher odds of periodontitis (OR = 1.43; 95% confidence interval (CI):1.0 ~ 2.03, p = 0.047) with SUA (≤ 3.3mg/dl) as reference. The risk of periodontitis tended to increase slightly but insignificantly with increasing SUA levels, and the adverse effects occurred only when SUA increased to a certain level, and then reached a plateau. In men, the adjusted OR values for SUA (4.9-5.2mg/dl), SUA (5.3-5.5mg/dl), SUA (5.9-6.2mg/dl), and SUA (6.3-6.5mg/dl) were 0.66 (95% CI: 0.45 ~ 0.96, p = 0.029), 0.58 (95% CI: 0.40 ~ 0.85, p = 0.006), 0.67(95% CI: 0.47 ~ 0.97, p = 0.035), and 0.67 (95% CI: 0.45 ~ 0.99, p = 0.043), respectively, with SUA (≤ 4.3mg/dl) as reference. The elevated SUA levels are protective against periodontitis, but there is a range within which the risk of periodontitis decreases, followed by a non-significant tendency to increase.
The levels of SUA that are linked to the risk of periodontitis. Future prospective longitudinal studies and strategies are required to further confirm whether controlled SUA treatment is an effective adjunct to systematic periodontal therapy and whether SUA can be used as a diagnostic biomarker to assess the risk or progression of periodontitis.
糖尿病和其他代谢性疾病与牙周炎的发展有关，但很少有研究确定血清尿酸（SUA）水平和高尿酸血症是否起作用。本研究旨在探讨 SUA、高尿酸血症与牙周炎之间的关系。
利用 2011-2014 年全国健康与营养调查（NHANES）的数据，创建了一个具有全国代表性的数据集。我们使用多变量逻辑回归模型来评估 SUA、高尿酸血症与牙周炎之间的关系，并分别呈现女性和男性的比值比（OR）。
在女性中，调整后的多变量回归模型显示，SUA（4.1-4.3mg/dl）与牙周炎的患病风险较高相关（OR=1.43；95%置信区间（CI）：1.02.03，p=0.047），以 SUA（≤3.3mg/dl）为参照。随着 SUA 水平的升高，牙周炎的患病风险略有但无统计学意义地增加，并且只有当 SUA 升高到一定水平时才会出现不良影响，然后达到一个平台期。在男性中，SUA（4.9-5.2mg/dl）、SUA（5.3-5.5mg/dl）、SUA（5.9-6.2mg/dl）和 SUA（6.3-6.5mg/dl）的调整后 OR 值分别为 0.66（95%CI：0.450.96，p=0.029）、0.58（95%CI：0.400.85，p=0.006）、0.67（95%CI：0.470.97，p=0.035）和 0.67（95%CI：0.45~0.99，p=0.043），以 SUA（≤4.3mg/dl）为参照。升高的 SUA 水平对牙周炎有保护作用，但存在一个风险降低的范围，随后呈现出非显著的增加趋势。
SUA 水平与牙周炎的风险相关。需要进一步进行前瞻性纵向研究和制定策略，以确定控制 SUA 治疗是否可作为系统牙周治疗的有效辅助手段，以及 SUA 是否可作为评估牙周炎风险或进展的诊断生物标志物。
