Cowley M J, Mullin S M, Kelsey S F, Kent K M, Gruentzig A R, Detre K M, Passamani E R
Circulation. 1985 Jan;71(1):90-7. doi: 10.1161/01.cir.71.1.90.
To assess whether gender influenced the outcome of percutaneous transluminal coronary angioplasty (PTCA), we analyzed data from the NHLBI PTCA Registry. Early results were compared in 705 women and 2374 men. Women were older (p less than .01) and had more unstable angina (p less than .01), and class 3 or 4 angina (p less than .01). Men had more multivessel disease (p less than .01), prior bypass surgery (p less than .01), and abnormal left ventricular function (p less than .05). Women had a lower angiographic success rate (60.3 vs 66.2%; p less than .01) and had a lower clinical success rate (56.6% vs 62.2%; p less than .01). More women had complications (27.2% vs 19.4%; p less than .01), but overall frequency of major complications (death, myocardial infarction, emergency surgery) was not different (9.8% vs 9.3%). Women had a higher incidence of coronary dissection (p less than .05) and higher in-hospital mortality (1.8% vs 0.7%; p less than .01). PTCA-related mortality was nearly six times higher in women (1.7% vs 0.3%; p less than .001) and mortality with emergency surgery was more than five time higher (17.4% vs 3.2%; p less than .001). Multivariate analysis indicated that female gender was an independent predictor for lower success (p less than .05) and early mortality (p less than .05) and was the only baseline predictor for PTCA-related mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
为评估性别是否会影响经皮腔内冠状动脉成形术（PTCA）的治疗结果，我们分析了美国国立心肺血液研究所（NHLBI）PTCA注册研究的数据。比较了705名女性和2374名男性的早期结果。女性年龄更大（p<0.01），不稳定型心绞痛更多（p<0.01），3或4级心绞痛更多（p<0.01）。男性多支血管病变更多（p<0.01），既往有搭桥手术史更多（p<0.01），左心室功能异常更多（p<0.05）。女性的血管造影成功率较低（60.3%对66.2%；p<0.01），临床成功率也较低（56.6%对62.2%；p<0.01）。更多女性出现并发症（27.2%对19.4%；p<0.01），但主要并发症（死亡、心肌梗死、急诊手术）的总体发生率并无差异（9.8%对9.3%）。女性冠状动脉夹层的发生率更高（p<0.05），住院死亡率更高（1.8%对0.7%；p<0.01）。与PTCA相关的死亡率在女性中几乎高出6倍（1.7%对0.3%；p<0.001），急诊手术相关的死亡率高出5倍多（17.4%对3.2%；p<0.001）。多变量分析表明，女性是成功率较低（p<0.05）和早期死亡率较高（p<0.05）的独立预测因素，并且是与PTCA相关死亡率的唯一基线预测因素。（摘要截短于250字）
