候选尿液生物标志物在胰腺癌中的表现 - 与胰腺囊性肿瘤恶性进展的相关性？
Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?
机构信息
Departments of Surgery, USA; Departments of Walther Oncology Center, USA; Departments of Indiana University Simon Cancer Center, USA; Departments of Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, USA.
Departments of Surgery, USA; Departments of Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, USA.
出版信息
Am J Surg. 2020 Mar;219(3):492-495. doi: 10.1016/j.amjsurg.2019.09.013. Epub 2019 Sep 17.
BACKGROUND
Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic cancer. Potential biomarkers of IPMN progression have not been identified in urine. A few urinary biomarkers were reported to be predictive of pancreatic ductal adenocarcinoma (PDAC). Here, we seek to assess their ability to detect high-risk IPMN.
METHODS
Urine was collected from patients undergoing pancreatic resection and healthy controls. TIMP-1(Tissue Inhibitor of Metalloproteinase-1), LYVE-1(Lymphatic Vessel Endothelial Receptor 1), and PGEM(Prostaglandin E Metabolite) levels were determined by ELISA and analyzed by Kruskal-Wallis.
RESULTS
Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12). No significant difference in urinary LYVE-1 was detected between IPMN low/moderate (n = 16; 0.37 ng/mg creatinine) and high/invasive grades (n = 21; 0.09). Urinary PGEM levels were not significantly different between groups.
CONCLUSIONS
Urinary TIMP-1, LYVE-1, and PGEM do not correlate with malignant potential of pancreatic cysts.
背景
导管内乳头状黏液性肿瘤（IPMN）是胰腺癌的前体。尚未在尿液中发现 IPMN 进展的潜在生物标志物。有报道称，一些尿液生物标志物可预测胰腺导管腺癌（PDAC）。在此，我们旨在评估它们检测高危 IPMN 的能力。
方法
收集接受胰腺切除术的患者和健康对照者的尿液。通过 ELISA 测定 TIMP-1（组织金属蛋白酶抑制剂-1）、LYVE-1（淋巴管内皮受体 1）和 PGEM（前列腺素 E 代谢物）的水平，并通过 Kruskal-Wallis 进行分析。
结果
与 PDAC（n=13；1.95）相比，健康对照组（n=9；0.32ng/mg 肌酐）的尿液 TIMP-1 中位水平显著降低，但在低/中等级（n=20；0.71）和高等级/侵袭性 IPMN（n=20；1.12）之间差异无统计学意义。在 IPMN 低/中等级（n=16；0.37ng/mg 肌酐）和高/侵袭性等级（n=21；0.09）之间，尿液 LYVE-1 无显著差异。各组间尿 PGEM 水平无显著差异。
结论
尿液 TIMP-1、LYVE-1 和 PGEM 与胰腺囊肿的恶性潜能无关。
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