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Inner Workings: Lyme disease vaccines face familiar challenges, both societal and scientific.

作者信息

Shaffer Leah

出版信息

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19214-19217. doi: 10.1073/pnas.1913923116.

DOI:10.1073/pnas.1913923116
PMID:31554734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6765291/
Abstract
摘要

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本文引用的文献

1
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission.反击蜱虫叮咬：针对病原体传播的抗蜱疫苗的合理设计。
Parasit Vectors. 2019 May 14;12(1):229. doi: 10.1186/s13071-019-3468-x.
2
Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.分析莱姆病螺旋体 OspC 蛋白的抗原决定簇：C10 基序不是免疫优势或产生杀菌抗体反应所必需的证据。
Vaccine. 2019 Apr 17;37(17):2401-2407. doi: 10.1016/j.vaccine.2019.02.007. Epub 2019 Mar 25.
3
The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes.新型莱姆病疫苗VLA15对表达六种不同OspA血清型的疏螺旋体物种具有广泛的保护作用。
PLoS One. 2017 Sep 1;12(9):e0184357. doi: 10.1371/journal.pone.0184357. eCollection 2017.
4
Vaccination against Lyme disease: past, present, and future.莱姆病疫苗接种：过去、现在和未来。
Front Cell Infect Microbiol. 2013 Feb 12;3:6. doi: 10.3389/fcimb.2013.00006. eCollection 2013.
5
Vaccines against Lyme disease: What happened and what lessons can we learn?莱姆病疫苗：发生了什么，我们可以吸取什么教训？
Clin Infect Dis. 2011 Feb;52 Suppl 3:s253-8. doi: 10.1093/cid/ciq116.
6
Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent.蜱组胺释放因子对于硬蜱的饱血和莱姆病病原体的传播是至关重要的。
PLoS Pathog. 2010 Nov 24;6(11):e1001205. doi: 10.1371/journal.ppat.1001205.
7
Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells.在单细胞水平上证实的莱姆关节炎中的分子模拟：淋巴细胞功能相关抗原-1αL是外表面蛋白A反应性T细胞的部分激动剂。
J Immunol. 2001 Apr 15;166(8):5286-91. doi: 10.4049/jimmunol.166.8.5286.