Baghdassarian R, Wright M W, Vaughn S A, Berns M W, Martin D C, Wile A G
J Urol. 1985 Jan;133(1):126-30. doi: 10.1016/s0022-5347(17)48820-3.
An obstacle to satisfactory treatment of early bladder cancer with hematoporphyrin derivative-photoradiation therapy is nonuniform illumination of the bladder mucosa. This study was done to determine the characteristics and attenuation of laser light passing through the dispersion medium. Bladder simulation was achieved with the use of 5 different sizes of round-bottom flasks. Intralipid was the dispersion medium. For each flask, 6 different concentrations of the dispersion medium were used. An Argon ion laser was used to stimulate a dye laser at 630 nm. The laser was directed toward the center of the flasks via a fiberoptic cable and energy concentration at 7 different angles was measured. We concluded that the optimal medium was a 1:100 dilution of Intralipid with water, which produced an almost uniform dispersion of light on the walls of the flask. There is a linear correlation between power as measured at the fiber tip and the amount of radiation detected on the walls of the flasks. After determining optimal concentration of medium, we calculated the amount of time needed for a desired energy (Joules/cm.2) to treat a tumor. This calculation was based on the size of the bladder and the power as measured at the fiber tip. The results indicate it is possible to treat the entire mucosa of the bladder with a uniform dose of photoradiation energy.
用血卟啉衍生物 - 光辐射疗法对早期膀胱癌进行满意治疗的一个障碍是膀胱黏膜的光照不均匀。本研究旨在确定激光穿过分散介质的特性和衰减情况。通过使用5种不同尺寸的圆底烧瓶来模拟膀胱。采用脂质体作为分散介质。对于每个烧瓶，使用6种不同浓度的分散介质。用氩离子激光激发630nm的染料激光。激光通过光纤电缆射向烧瓶中心，并测量7个不同角度的能量集中度。我们得出结论，最佳介质是脂质体与水按1:100稀释，这在烧瓶壁上产生了几乎均匀的光散射。光纤尖端测得的功率与烧瓶壁上检测到的辐射量之间存在线性关系。确定介质的最佳浓度后，我们计算了用所需能量（焦耳/平方厘米）治疗肿瘤所需的时间。该计算基于膀胱的大小和光纤尖端测得的功率。结果表明，用均匀剂量的光辐射能量治疗膀胱的整个黏膜是可能的。
