Nseyo U O, Dougherty T J, Boyle D, Potter W, Englander L S, Huben R P, Pontes J E
J Urol. 1985 Feb;133(2):311-5. doi: 10.1016/s0022-5347(17)48929-4.
In urology, important limiting factors in the application of hematoporphyrin derivative and photodynamic therapy appear to be the problems of standardization of dosimetry and the technique of transurethral photoradiation. Experimental photodynamic therapy on canine bladder with normal and altered epithelium was performed using an argon laser as an energy source. A 630 nanometer wavelength of light was delivered through a quartz-optical fiber with either a regular flat end for focal illumination or a bulb-type end which produced an isotropic light pattern. It was demonstrated that normal canine bladder was resistant to photodynamic therapy and that the bulb tip produced whole bladder illumination. With a moderate light dose of 18 to 30 Joules/cm.2 the effect following whole bladder illumination on the bladder was generalized and superficial. This approach appears to be ideal for treating superficial transitional cell carcinoma of the bladder. Additional work is needed in selecting appropriate energy doses.
在泌尿学领域，血卟啉衍生物和光动力疗法应用中的重要限制因素似乎是剂量测定的标准化问题以及经尿道光辐射技术。以氩激光作为能量源，对具有正常和改变上皮的犬膀胱进行了实验性光动力疗法。630纳米波长的光通过石英光纤传输，该光纤一端为用于聚焦照明的常规扁平端，另一端为产生各向同性光模式的灯泡型端。结果表明，正常犬膀胱对光动力疗法具有抗性，且灯泡型尖端可实现全膀胱照明。在18至30焦耳/平方厘米的中等光剂量下，全膀胱照明对膀胱的影响是广泛而表浅的。这种方法似乎是治疗膀胱浅表移行细胞癌的理想方法。在选择合适的能量剂量方面还需要进一步研究。
