Ahmadian Elham, Dizaj Solmaz Maleki, Eftekhari Aziz, Dalir Elaheh, Vahedi Parviz, Hasanzadeh Amir, Samiei Mohammad
Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Res (Stuttg). 2020 Jan;70(1):6-11. doi: 10.1055/a-0991-7585. Epub 2019 Sep 25.
Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.
透明质酸（HA）因其生物相容性、生物可降解性和无毒特性而在生物医学中得到广泛应用。它在形态发生、炎症和伤口修复过程中的细胞信号传导作用至关重要。形成水凝胶后，HA易于转化为弹性片材，以便用于临床前和临床应用。此外，HA衍生的水凝胶在组织修复和再生医学中很容易用作细胞和药物的载体。此外，与其他聚合物相比，基于HA的水凝胶在细胞行为（包括干细胞分化）中起关键作用。本文综述了用于生物医学应用的基于HA的水凝胶的基本概念和最新进展。
