Galla Rebecca, Mulè Simone, Ferrari Sara, Molinari Claudio, Uberti Francesca
Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, University of Piemonte Orientale, UPO, 13100 Vercelli, Italy.
Noivita S.r.l.s., Spin Off of University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
Int J Mol Sci. 2025 Jan 22;26(3):897. doi: 10.3390/ijms26030897.
Hyaluronic acid (HA) represents a pivotal component of the extracellular matrix, particularly within the context of the skin. The absorption and metabolism of orally ingested HA have been extensively investigated due to the prevalence of HA-based supplements. The objective of this study was to evaluate the impact of a combination of non-animal HA and novaBLG1 on dermal health following intestinal transit. The bioavailability of the compound was evaluated using a model that reproduced the human intestinal barrier in vitro, and its biological effects were investigated on skin cells via the gut-skin axis. The results demonstrated that probiotics augmented the absorption of non-animal HA by approximately 30% in comparison to non-animal HA alone and by 82% in comparison to sodium hyaluronate. Furthermore, the combination demonstrated a notable enhancement in skin cell proliferation, with increases of 16%, 8%, and 29.7% over 144 h in comparison to non-animal hyaluronan, novaBLG1, and sodium hyaluronate, respectively. The combination was observed to positively affect all markers of skin health and well-being, achieving its goals without any adverse effects on the gut. This approach offers a novel method for enhancing skin health.
透明质酸（HA）是细胞外基质的关键组成部分，在皮肤环境中尤为如此。由于基于HA的补充剂很普遍，口服摄入的HA的吸收和代谢已得到广泛研究。本研究的目的是评估非动物源HA与novaBLG1组合在肠道转运后对皮肤健康的影响。使用体外重现人类肠道屏障的模型评估该化合物的生物利用度，并通过肠-皮轴研究其对皮肤细胞的生物学效应。结果表明，与单独使用非动物源HA相比，益生菌使非动物源HA的吸收增加了约30%，与透明质酸钠相比增加了82%。此外，该组合在皮肤细胞增殖方面表现出显著增强，与非动物源透明质酸、novaBLG1和透明质酸钠相比，在144小时内分别增加了16%、8%和29.7%。观察到该组合对皮肤健康和福祉的所有指标都有积极影响，在不对肠道产生任何不良影响的情况下实现了目标。这种方法为改善皮肤健康提供了一种新途径。
