Assistant Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
M.B.B.Ch, Benghazi University, Benghazi, Libya.
J Dermatolog Treat. 2020 Dec;31(8):758-762. doi: 10.1080/09546634.2019.1670778. Epub 2019 Oct 10.
Psoriasis-specific proteins dysregulated in keratinocytes and involved in the pathophysiological process of psoriasis remains elusive. This study aimed to investigate the serum and tissue levels of Galectin3 in patients with psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy. This study was designed as a cross-sectional case-control. This study included 30 patients with psoriasis Vulgaris and 20 healthy individuals. Psoriasis Area and Severity Index (PASI) score were used to evaluate the patients with psoriasis Vulgaris before and after treatment. All patients were treated two times per week for 3 months with NB-UVB phototherapy. Enzyme-linked immunosorbent assay (ELISA) was used to assess serum levels of galectin 3 of the healthy control subjects and psoriatic patients before and after treatment by NB-UVB phototherapy. The serum level of galectin 3 was significantly lower in patients with psoriasis Vulgaris versus healthy control subjects ( value < .001). There was a significant increase in the serum levels of Galectin 3 and decrease in PASI scores after 3 months of treatment with NB-UVB phototherapy in patients with psoriasis Vulgaris ( value < .001). This study concluded that NB-UVB phototherapy for 3 months in patients with psoriasis Vulgaris was an essential method for decreasing PASI scores and an increase in the serum levels of galectin 3.
寻常型银屑病患者角质形成细胞中失调的银屑病特异性蛋白及其在银屑病发病机制中的作用仍不清楚。本研究旨在探讨窄谱中波紫外线（NB-UVB）光疗前后寻常型银屑病患者血清和组织中半乳糖凝集素 3（Galectin3）的水平。本研究设计为横断面病例对照研究。本研究纳入了 30 例寻常型银屑病患者和 20 名健康对照者。采用银屑病面积和严重程度指数（PASI）评分评估寻常型银屑病患者治疗前后的病情。所有患者每周接受 2 次 NB-UVB 光疗，共治疗 3 个月。采用酶联免疫吸附试验（ELISA）检测健康对照者和 NB-UVB 光疗前后寻常型银屑病患者血清 Galectin3 水平。与健康对照组相比，寻常型银屑病患者的血清 Galectin3 水平显著降低（ value <.001）。寻常型银屑病患者接受 NB-UVB 光疗 3 个月后，血清 Galectin3 水平显著升高，PASI 评分降低（ value <.001）。本研究得出结论，NB-UVB 光疗 3 个月是寻常型银屑病患者降低 PASI 评分和增加血清 Galectin3 水平的重要方法。
