窄谱中波紫外线光疗对寻常型银屑病患者可溶性细胞黏附分子的影响。
Effect of narrow-band UVB phototherapy on soluble cell adhesion molecules in patients with psoriasis vulgaris.
作者信息
Long J W, Tao J, Pi X M, Wang Y Y, Tu Y T
机构信息
Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
J Int Med Res. 2010 Jul-Aug;38(4):1507-12. doi: 10.1177/147323001003800434.
This study investigated the effect of narrow-band ultraviolet B (NB-UVB) phototherapy on serum levels of the soluble cell adhesion molecules sE-selectin, sP-selectin, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) in 58 patients with psoriasis vulgaris. Psoriasis Area and Severity Index (PASI) scores significantly decreased after treatment, confirming the efficacy of NB-UVB phototherapy. Serum levels of sE-selectin also decreased significantly after treatment, and levels of sICAM-1 showed a significant correlation with PASI score and with levels of sE-selectin. The efficacy of NB-UVB phototherapy in improving psoriatic lesions may be a function of decreased serum levels of E-selectin. These findings emphasize the complex roles of soluble cell adhesion molecules in the immunopathogenesis of psoriasis.
本研究调查了窄谱中波紫外线（NB-UVB）光疗对58例寻常型银屑病患者血清中可溶性细胞黏附分子sE-选择素、sP-选择素、sL-选择素及可溶性细胞间黏附分子-1（sICAM-1）水平的影响。治疗后银屑病面积和严重程度指数（PASI）评分显著降低，证实了NB-UVB光疗的疗效。治疗后血清sE-选择素水平也显著降低，且sICAM-1水平与PASI评分及sE-选择素水平显著相关。NB-UVB光疗改善银屑病皮损的疗效可能与血清E-选择素水平降低有关。这些发现强调了可溶性细胞黏附分子在银屑病免疫发病机制中的复杂作用。
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