Giler S, Kupfer B, Urca I, Moroz C
Surg Gynecol Obstet. 1979 Nov;149(5):655-7.
A cytotoxic assay for the identification of circulating lymphocytes bearing surface ferritin was performed on 100 patients with malignant disease of the breast and in 50 healthy women. Forty-five patients were found to have a subpopulation of ferritin bearing lymphocytes, and all of them proved to have Stages I and II carcinoma of the breast. No such lymphocytes were identified in normal women, and in the remaining 55 patients, 33 had benign disease of the breast, 20 had Stage III carcinoma of the breast and two had Stages I and II carc-noma of the breast. It appears that this immunodiagnostic test may provide an additional tool for the early detection of carcinoma of the breast and may have a prognostic implication.
对100例乳腺癌患者和50名健康女性进行了一项细胞毒性试验，以鉴定携带表面铁蛋白的循环淋巴细胞。发现45例患者存在携带铁蛋白的淋巴细胞亚群，且所有这些患者均被证实患有I期和II期乳腺癌。在正常女性以及其余55例患者中未发现此类淋巴细胞，其中33例患有乳腺良性疾病，20例患有III期乳腺癌，2例患有I期和II期乳腺癌。看来这种免疫诊断试验可能为乳腺癌的早期检测提供一种额外的工具，并且可能具有预后意义。
