Moroz C, Kupfer B
Isr J Med Sci. 1981 Sep-Oct;17(9-10):879-81.
In patients with early stages (I, II) of breast cancer we identified a subset of circulating lymphocytes that carry ferritin on their surface. No such lymphocytes were identified in normal women nor in women with benign breast disease. These cells did not form spontaneous rosettes with sheep red blood cells. Further studies revealed that in vitro treatment of the patients' lymphocytes with levamisole resulted n the removal of the surface ferritin and in an increase in the reactivity of the lymphocytes in mixed lymphocyte culture (MLC). Separation of the ferritin-positive lymphocytes from the E-rosetting T cells resulted in an increased reactivity of the patients' T cells in MLC. Readdition of the fraction containing the ferritin-positive cells to a mixed lymphocyte culture resulted in a decrease in the proliferative response of the patients' T lymphocytes. It is suggested that the ferritin-positive lymphocytes in breast cancer patients represent an active suppressor cell subset.
在早期（I、II期）乳腺癌患者中，我们发现了一部分循环淋巴细胞，其表面带有铁蛋白。在正常女性和患有良性乳腺疾病的女性中未发现此类淋巴细胞。这些细胞不会与绵羊红细胞形成自发玫瑰花结。进一步研究表明，用左旋咪唑对患者淋巴细胞进行体外处理，可导致表面铁蛋白去除，并使淋巴细胞在混合淋巴细胞培养（MLC）中的反应性增加。将铁蛋白阳性淋巴细胞与E玫瑰花结形成T细胞分离，可导致患者T细胞在MLC中的反应性增加。将含有铁蛋白阳性细胞的组分重新添加到混合淋巴细胞培养物中，会导致患者T淋巴细胞的增殖反应降低。提示乳腺癌患者中，铁蛋白阳性淋巴细胞代表一个活跃的抑制性细胞亚群。
