Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Clin Oral Implants Res. 2020 Jan;31(1):49-63. doi: 10.1111/clr.13546. Epub 2019 Nov 6.
To compare the contributions of implant hydrophilicity and nanotopography on anchorage in bone. The effect of elevated calcium surface chemistry on bone anchorage was also investigated.
A full factorial study design was implemented to evaluate the effects of ultraviolet (UV) light and/or sodium lactate (SL) and discrete crystalline deposition of nanocrystals (DCD) treatments on the osseointegration of dual acid-etched (AE) titanium alloy (Ti6Al4V) and grit blasted and AE (BAE) commercially pure titanium (CpTi) implants. Sodium hydroxide (NaOH)-treated CpTi implants were immersed in simulated body fluid (SBF) to increase calcium surface chemistry. Implants were placed in the femora of Wistar rats and tested using pull-out testing (BAE implants: 5, 9, 14 days) or tensile testing (AE implants: 9 days, NaOH implants: 28 days).
Ti6Al4V-AE implants with DCD- and UV-treated surfaces significantly increased bone anchorage compared with untreated Ti6Al4V-AE alloy implants. Pull-out testing of BAE-CpTi implants with the DCD treatment showed increased disruption force values compared with surfaces without the DCD treatment at 5, 9 and 14 days by 4.1N, 13.9N and 15.5N, respectively, and UV-treated implants showed an increase at 14 days by 8.4N. No difference was found between NaOH + SBF and NaOH + H O groups.
Bone anchorage of implants was found to be improved by UV-treating implants or nanotopographically complex surfaces. However, implant nanotopography was found to have a greater contribution to the overall bone anchorage and is more consistent compared with the time-dependent nature of the UV treatment.
比较种植体亲水性和纳米形貌对骨锚固的贡献。还研究了提高钙表面化学对骨锚固的影响。
采用完全因子设计研究方案来评估紫外线 (UV) 光和/或乳酸钠 (SL) 以及纳米晶体离散沉积 (DCD) 处理对双酸蚀 (AE) 钛合金 (Ti6Al4V) 和喷砂酸蚀 (BAE) 商用纯钛 (CpTi) 种植体的骨整合的影响。将氢氧化钠 (NaOH) 处理的 CpTi 种植体浸入模拟体液 (SBF) 中以增加钙表面化学。将种植体放置在 Wistar 大鼠的股骨中，并通过拔出试验 (BAE 种植体：5、9、14 天) 或拉伸试验 (AE 种植体：9 天，NaOH 种植体：28 天) 进行测试。
与未经处理的 Ti6Al4V-AE 合金种植体相比，具有 DCD 和 UV 处理表面的 Ti6Al4V-AE 种植体显著增加了骨锚固。在 5、9 和 14 天，具有 DCD 处理的 BAE-CpTi 种植体的拔出试验显示，与无 DCD 处理的表面相比，破坏力值分别增加了 4.1N、13.9N 和 15.5N，而经过 UV 处理的种植体在 14 天时增加了 8.4N。NaOH+SBF 和 NaOH+H2O 组之间没有差异。
发现通过 UV 处理种植体或纳米形貌复杂的表面可以改善种植体的骨锚固。然而，与 UV 处理的时间依赖性相比，种植体纳米形貌对整体骨锚固的贡献更大且更一致。
