Stavropoulos Andreas, Sandgren Rebecca, Bellon Benjamin, Sculean Anton, Pippenger Benjamin E
Division of Regenerative Dental Medicine and Periodontology, University of Geneva, CH-1211 Genève 4, Switzerland.
Department of Periodontology, Faculty of Odontology, Malmö University, SE-205 06 Malmö, Sweden.
Materials (Basel). 2021 Mar 29;14(7):1678. doi: 10.3390/ma14071678.
Surface chemistry and nanotopography of dental implants can have a substantial impact on osseointegration. The aim of this investigation was to evaluate the effects of surface chemistry and nanotopography on the osseointegration of titanium-zirconium (TiZr; Roxolid) discs, using a biomechanical pull-out model in rabbits. Two discs each were placed in both the right and left tibiae of 16 rabbits. Five groups of sandblasted acid etched (SLA) discs were tested: (1) hydrophobic without nanostructures (dry/micro) ( = 13); (2) hydrophobic with nanostructures, accelerated aged (dry/nano/AA) ( = 12); (3) hydrophilic without nanostructures (wet/micro) ( = 13); (4) hydrophilic with nanostructures, accelerated aged (wet/nano/AA; SLActive) ( = 13); (5) hydrophilic with nanostructures, real-time aged (wet/nano/RTA). The animals were sacrificed after four weeks and the biomechanical pull-out force required to remove the discs was evaluated. Adjusted mean pull-out force was greatest for group wet/nano/RTA (64.5 ± 17.7 N) and lowest for group dry/micro (33.8 ± 10.7 N). Multivariate mixed model analysis showed that the pull-out force was significantly greater for all other disc types compared to the dry/micro group. Surface chemistry and topography both had a significant effect on pull-out force ( < 0.0001 for both), but the effect of the interaction between chemistry and topography was not significant ( = 0.1056). The introduction of nanostructures on the TiZr surface significantly increases osseointegration. The introduction of hydrophilicity to the TiZr implant surface significantly increases the capacity for osseointegration, irrespective of the presence or absence of nanotopography.
牙种植体的表面化学性质和纳米形貌对骨结合有着重大影响。本研究的目的是使用兔生物力学拔出模型，评估表面化学性质和纳米形貌对钛锆（TiZr；Roxolid）盘片骨结合的影响。在16只兔子的左右胫骨中各植入两片盘片。测试了五组喷砂酸蚀（SLA）盘片：（1）无纳米结构的疏水型（干/微）（ = 13）；（2）有纳米结构的疏水型，加速老化（干/纳米/AA）（ = 12）；（3）无纳米结构的亲水型（湿/微）（ = 13）；（4）有纳米结构的亲水型，加速老化（湿/纳米/AA；SLActive）（ = 13）；（5）有纳米结构的亲水型，实时老化（湿/纳米/RTA）。四周后处死动物，评估取出盘片所需的生物力学拔出力。湿/纳米/RTA组的调整后平均拔出力最大（64.5±17.7 N），干/微组最低（33.8±10.7 N）。多变量混合模型分析表明，与干/微组相比，所有其他盘片类型的拔出力均显著更大。表面化学性质和形貌对拔出力均有显著影响（两者均<0.0001），但化学性质与形貌之间相互作用的影响不显著（ = 0.1056）。在TiZr表面引入纳米结构可显著提高骨结合。在TiZr种植体表面引入亲水性可显著提高骨结合能力，无论是否存在纳米形貌。
