From the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, NY.
Epidemiology. 2019 Nov;30 Suppl 2(Suppl 2):S37-S46. doi: 10.1097/EDE.0000000000001066.
Although fatty acids are involved in critical reproductive processes, the relationship between specific fatty acids and fertility is uncertain. We investigated the relationship between preconception plasma fatty acids and pregnancy outcomes.
We included 1,228 women attempting pregnancy with one to two previous pregnancy losses from the EAGeR trial (2007-2011). Plasma fatty acids were measured at baseline. We used log-binomial regression to assess associations between fatty acids and pregnancy, pregnancy loss, and live birth, adjusting for age, race, smoking, BMI, physical activity, income, parity, treatment arm, and cholesterol.
Although total saturated fatty acids (SFAs) were not associated with pregnancy outcomes, 14:0 (myristic acid; relative risk [RR] = 1.10, 95% confidence interval [CI] = 1.02, 1.19, per 0.1% increase) and 20:0 (arachidic acid; RR = 1.05, 95% CI = 1.01, 1.08, per 0.1% increase) were positively associated with live birth. Findings suggested a positive association between total monounsaturated fatty acids (MUFAs) and pregnancy and live birth and an inverse association with loss. Total polyunsaturated fatty acids (PUFAs) were associated with lower probability of pregnancy (RR = 0.97, 95% CI = 0.95, 1.00) and live birth (RR = 0.96, 95% CI = 0.94, 0.99), and increased risk of loss (RR = 1.10, 95% CI = 1.00, 1.20), per 1% increase. Trans fatty acids and n-3 fatty acids were not associated with pregnancy outcomes.
Preconception total plasma MUFAs were positively associated with pregnancy and live birth. PUFAs were inversely associated with pregnancy outcomes. Specific SFAs were associated with a higher probability of live birth. Our results suggest that fatty acids may influence pregnancy outcomes.
尽管脂肪酸与关键的生殖过程有关，但特定脂肪酸与生育能力之间的关系尚不确定。我们研究了孕前血浆脂肪酸与妊娠结局之间的关系。
我们纳入了 EAGeR 试验（2007-2011 年）中 1228 名有一次或两次既往妊娠丢失且正在尝试妊娠的女性。在基线时测量血浆脂肪酸。我们使用对数二项式回归来评估脂肪酸与妊娠、妊娠丢失和活产之间的关联，调整了年龄、种族、吸烟、BMI、身体活动、收入、产次、治疗臂和胆固醇。
尽管总饱和脂肪酸（SFAs）与妊娠结局无关，但 14:0（肉豆蔻酸；相对风险 [RR] = 1.10，95%置信区间 [CI] = 1.02，1.19，每增加 0.1%）和 20:0（花生四烯酸；RR = 1.05，95% CI = 1.01，1.08，每增加 0.1%）与活产呈正相关。研究结果表明，总单不饱和脂肪酸（MUFAs）与妊娠和活产呈正相关，与丢失呈负相关。总多不饱和脂肪酸（PUFAs）与妊娠（RR = 0.97，95%CI = 0.95，1.00）和活产（RR = 0.96，95%CI = 0.94，0.99）的可能性降低有关，每增加 1%，丢失的风险增加（RR = 1.10，95%CI = 1.00，1.20）。反式脂肪酸和 n-3 脂肪酸与妊娠结局无关。
孕前总血浆 MUFA 与妊娠和活产呈正相关。PUFAs 与妊娠结局呈负相关。特定 SFA 与活产的可能性增加有关。我们的研究结果表明，脂肪酸可能影响妊娠结局。
