脂肪细胞因子作为危重病和脓毒症的循环生物标志物的作用。
The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis.
机构信息
Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Augustenburger Platz 1, 10117 Berlin, Germany.
出版信息
Int J Mol Sci. 2019 Sep 28;20(19):4820. doi: 10.3390/ijms20194820.
Abstract
Sepsis represents a major global health burden. Early diagnosis of sepsis as well as guiding early therapeutic decisions in septic patients still represent major clinical challenges. In this context, a whole plethora of different clinical and serum-based markers have been tested regarding their potential for early detection of sepsis and their ability to stratify patients according to their probability to survive critical illness and sepsis. Adipokines represent a fast-growing class of proteins that have gained an increasing interest with respect to their potential to modulate immune responses in inflammatory and infectious diseases. We review current knowledge on the role of different adipokines in diagnostic work-up and risk stratification of sepsis as well as critical illness. We discuss recent data from animal models as well as from clinical studies and finally highlight the limitations of these analyses that currently prevent the use of adipokines as biomarkers in daily practice.
摘要
脓毒症是一个全球性的重大健康负担。脓毒症的早期诊断以及指导脓毒症患者的早期治疗决策仍然是主要的临床挑战。在这种情况下，已经测试了大量不同的临床和基于血清的标志物，以评估它们在早期检测脓毒症方面的潜力，并根据患者存活严重疾病和脓毒症的可能性对其进行分层。脂肪因子是一类快速增长的蛋白质，它们在调节炎症和感染性疾病中的免疫反应方面的潜力引起了越来越多的关注。我们综述了不同脂肪因子在脓毒症及严重疾病的诊断和风险分层中的作用的现有知识。我们讨论了来自动物模型以及临床研究的最新数据，并最终强调了这些分析的局限性，这些局限性目前阻止了将脂肪因子用作日常实践中的生物标志物。
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