Dong Chao, Zhang Xiying, Liu Kaiqing, Li Bojiang, Chao Zhe, Jiang Aiwen, Li Rongyang, Li Pinghua, Liu Honglin, Wu Wangjun
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Animals (Basel). 2019 Sep 29;9(10):744. doi: 10.3390/ani9100744.
is involved in muscle fiber conversion, adult-onset obesity, and type 2 diabetes. However, information regarding porcine and its relationship with meat quality traits is still unknown. In this study, we characterized the full-length cDNA and proximal promoter of two transcript variants of porcine . Moreover, was expressed abundantly in the skeletal muscle and its expression was higher in the soleus muscle than that in the biceps femoris muscle. Its expression pattern in the high and low meat color (redness) value * groups was similar to that of and , but opposed to that of . Importantly, there was a significant positive correlation between expression and meat color (redness) value * (r = 0.3845, = 0.0394), and a significant negative correlation between expression and drip loss (r = -0.4204, = 0.0232), as well as the ratio of to expression (r = -0.3871, = 0.0380). In addition, we found that the polymorphisms of three closely linked SNPs in promoter 1 were significantly associated with pH in a pig population. Taken together, our data provide valuable insights into the characteristics of porcine and indicate that is a promising candidate gene affecting meat quality traits.
参与肌纤维转化、成年期肥胖和2型糖尿病。然而，关于猪的[具体基因名称未给出]及其与肉质性状关系的信息仍然未知。在本研究中，我们对猪的[具体基因名称未给出]两个转录变体的全长cDNA和近端启动子进行了表征。此外，[具体基因名称未给出]在骨骼肌中大量表达，并且其在比目鱼肌中的表达高于股二头肌中的表达。其在高肉色（红色度）值组和低肉色（红色度）值组中的表达模式与[其他相关基因名称未给出]和[其他相关基因名称未给出]相似，但与[其他相关基因名称未给出]相反。重要的是，[具体基因名称未给出]表达与肉色（红色度）值*之间存在显著正相关（r = 0.3845，P = 0.0394），[具体基因名称未给出]表达与滴水损失之间存在显著负相关（r = -0.4204，P = 0.0232），以及[具体基因名称未给出]与[其他相关基因名称未给出]表达的比值之间存在显著负相关（r = -0.3871，P = 0.0380）。此外，我们发现[具体基因名称未给出]启动子1中三个紧密连锁的单核苷酸多态性（SNP）的多态性与猪群体中的pH值显著相关。综上所述，我们的数据为猪的[具体基因名称未给出]特性提供了有价值的见解，并表明[具体基因名称未给出]是影响肉质性状的一个有前景的候选基因。
