Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.
Department of Obstetrics and Gynecology, Clinic University Hospital of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Int J Environ Res Public Health. 2019 Sep 27;16(19):3638. doi: 10.3390/ijerph16193638.
To analyze if non-surgical treatment of periodontitis in a pregnant Caucasian women population can reduce adverse pregnancy outcomes.
A parallel randomized clinical trial was designed and approved by the Ethical Committee of Sanitary Area Santiago-Lugo, Spain (registration number: 2016/451). Forty patients with periodontitis stage II grade B were randomly allocated to receive either comprehensive non-surgical periodontal therapy (test group; = 20) or professional tooth cleaning (control group; = 20) before 24 gestational weeks. Randomization was computer-generated by the statistic program Epidat v.4.1 and allocation was performed using sealed opaque envelopes. Clinical measurements and peripheral blood samples for biochemical variables were collected at baseline, in the middle of second trimester before non-surgical treatment, and in the third trimester. Microbiological samples were collected in the second and third trimester. A statistically significant reduction was verified in all clinical and microbiological parameters after periodontal treatment in the test group. No significant differences were observed for the rest of the variables, including preterm birth and/or low birth weight. No adverse events related to periodontal treatment were reported.
Non-surgical periodontal treatment in Caucasian patients with periodontitis stage II grade B did not significantly reduce the risk of adverse pregnancy outcomes.
分析对患有牙周炎的白种人孕妇进行非手术治疗是否可以降低不良妊娠结局的发生风险。
设计了一项平行随机临床试验，并经西班牙圣地亚哥-卢戈卫生区伦理委员会批准（注册号：2016/451）。将 40 名患有牙周炎 2 期 B 级的患者随机分配，分别接受综合非手术牙周治疗（试验组，n=20）或专业洁牙（对照组，n=20），治疗时间均在 24 孕周前。通过 Epidat v.4.1 统计程序生成随机数，并使用密封不透明信封进行分组。在基线、中孕期（非手术治疗前）和孕晚期收集临床测量和外周血生化变量样本。在孕中期和孕晚期采集微生物样本。在试验组中，牙周治疗后所有临床和微生物学参数均显著降低。其余变量（包括早产和/或低出生体重）未见显著差异。未报告与牙周治疗相关的不良事件。
对白种人牙周炎 2 期 B 级患者进行非手术牙周治疗并不能显著降低不良妊娠结局的发生风险。
