Inserm, CIC 1413, centre de prévention des maladies infectieuses et transmissibles, centre hospitalo-universitaire de Nantes, 5, rue du Professeur-Yves-Boquien, 44000 Nantes, France; Inserm, CIC 1413, service de maladies infectieuses et tropicales, centre hospitalo-universitaire de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.
Service de médecine interne et maladies infectieuses, l'hôpital privé du confluent, 2-4, rue Eric-Tabarly, 44200 Nantes, France.
Med Mal Infect. 2019 Nov;49(8):593-601. doi: 10.1016/j.medmal.2019.09.001. Epub 2019 Sep 27.
Protection of French young infants against pertussis only relies on their relatives' vaccination. The alternative is vaccination of pregnant women against pertussis (cocooning strategy), but this strategy is not yet recommended in France. We assessed the acceptance of this strategy among French postpartum women and health professionals.
We performed a multicenter survey in 2016 among postpartum women and health professionals (family physicians, obstetricians-gynecologists, midwives, and medical students) to determine the acceptance of anti-pertussis vaccination. We evaluated knowledge, perception, and attitude towards vaccination to identify factors associated with acceptance.
Questionnaires were completed by 52% (1208/2337) of women and 40% (694/1754) of health professionals. Seventy-seven per cent of women (95% CI: 74-79) and 93% of health professionals (95% CI: 91-95) were favorable to anti-pertussis vaccination of pregnant women. Thirty-three per cent (227/687) of health professionals believed that pertussis induced life-long immunity and 20% (136/687) of them were not aware of the cocooning strategy. In multivariate analysis, factors associated with acceptance among women were younger age, higher knowledge, having received advice during pregnancy, being vaccinated against influenza, and having never refused any vaccine; among health professionals, factors associated with acceptance were belief that inactivated vaccines are obstetrically safe, regular practice of influenza vaccination in pregnant women, pertussis cocooning strategy, and never prescribing preventive homeopathy for influenza.
Vaccination of pregnant women against pertussis should be well-accepted by informed mothers and health professionals. If this strategy were to be implemented in France, efforts should be made towards adequate information.
保护法国的婴幼儿免受百日咳的侵害，只能依靠他们的亲属接种疫苗。另一种方法是给孕妇接种百日咳疫苗（疫苗保护策略），但该策略在法国尚未得到推荐。我们评估了法国产后妇女和卫生专业人员对该策略的接受程度。
我们于 2016 年在产后妇女和卫生专业人员（家庭医生、妇产科医生、助产士和医学生）中进行了一项多中心调查，以确定对接种疫苗的接受程度。我们评估了对疫苗接种的知识、看法和态度，以确定与接受程度相关的因素。
有 52%（1208/2337）的女性和 40%（694/1754）的卫生专业人员完成了问卷调查。77%（95%置信区间：74-79）的女性和 93%（95%置信区间：91-95）的卫生专业人员赞成给孕妇接种百日咳疫苗。33%（227/687）的卫生专业人员认为百日咳会产生终身免疫力，20%（136/687）的卫生专业人员不知道疫苗保护策略。在多变量分析中，与女性接受程度相关的因素是年龄较小、知识水平较高、在怀孕期间得到过建议、接种过流感疫苗，并且从未拒绝过任何疫苗；与卫生专业人员接受程度相关的因素是认为灭活疫苗对产科安全、定期给孕妇接种流感疫苗、实施百日咳疫苗保护策略，以及从不开预防流感顺势疗法药物。
知情的母亲和卫生专业人员应该会很好地接受给孕妇接种百日咳疫苗。如果该策略在法国实施，应努力提供充分的信息。
