心电图左心室肥厚与高龄高血压中国人群的死亡率。
Electrocardiographic left ventricular hypertrophy and mortality in an oldest-old hypertensive Chinese population.
机构信息
Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.
出版信息
Clin Interv Aging. 2019 Sep 17;14:1657-1662. doi: 10.2147/CIA.S218106. eCollection 2019.
PURPOSE
Previous studies have identified that electrocardiographic pattern of left ventricular hypertrophy (ECG LVH) is associated with mortality, but studies of its correlation in the oldest-old hypertensive population is extremely limited. We investigated the correlation between ECG LVH and mortality in a hypertensive Chinese population aged 80 years and older.
PATIENTS AND METHODS
In this study, we included 284 Chinese participants older than 80 years. All included participants with hypertension (sitting systolic blood pressure [BP] 160 to 200 mmHg; sitting diastolic BP <110 mmHg) were ascertained at the baseline. ECG LVH was defined as a Sokolow-Lyon voltage calculated as the amplitude of SV1+ (max RV5 or RV6) greater than 3.5 mV. We categorized participants into two groups by the status of baseline ECG LVH. We used Cox regression models to calculate hazard ratio (HRs) for mortality due to ECG LVH, including cardiovascular mortality and all-cause mortality.
RESULTS
In this study, with a 28-month median follow-up, a total of 35 (12.3%) patients died; 21 of those died due to cardiovascular causes. Compared with participants without ECG LVH, there was an increased risk of cardiovascular mortality in participants with ECG LVH (adjusted HR 4.25 [95% confidence interval [CI], 1.50-12.06]) but ECG LVH did not predict all-cause mortality (adjusted HR 2.31 [95% CI, 0.93-5.72]).
CONCLUSION
Our study shows that ECG LVH predicts the risk of cardiovascular mortality in an oldest-old hypertensive Chinese population.
目的
先前的研究已经确定心电图左心室肥厚（ECG LVH）模式与死亡率相关，但对最年长的高血压人群中其相关性的研究极为有限。我们研究了心电图 LVH 与 80 岁及以上高血压中国人群死亡率之间的相关性。
患者和方法
本研究纳入了 284 名 80 岁以上的中国参与者。所有纳入的高血压参与者（坐位收缩压 [BP] 160-200mmHg；坐位舒张压 <110mmHg）在基线时确定。心电图 LVH 定义为 SV1+（最大 RV5 或 RV6）振幅大于 3.5 mV 的 Sokolow-Lyon 电压。我们根据基线心电图 LVH 的状态将参与者分为两组。我们使用 Cox 回归模型计算心电图 LVH 导致的死亡率（包括心血管死亡率和全因死亡率）的风险比（HRs）。
结果
在这项研究中，中位随访 28 个月，共有 35 名（12.3%）患者死亡；其中 21 人死于心血管原因。与无心电图 LVH 的参与者相比，心电图 LVH 的参与者发生心血管死亡率的风险增加（调整后的 HR 4.25 [95%置信区间 [CI]，1.50-12.06]），但心电图 LVH 并未预测全因死亡率（调整后的 HR 2.31 [95% CI，0.93-5.72]）。
结论
我们的研究表明，心电图 LVH 预测了一个最年长的高血压中国人群中心血管死亡率的风险。
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