磷脂酰乙醇胺结合蛋白4在肿瘤中的作用及信号通路
The Roles And Signaling Pathways Of Phosphatidylethanolamine-Binding Protein 4 In Tumors.
作者信息
Luo Zi-Kang, Chen Qiong-Feng, Qu Xiaoqin, Zhou Xiao-Yan
机构信息
Department of Clinical Medical, The Second Clinical Medical College, Nanchang University, Nanchang 330006, People's Republic of China.
Department of Pathophysiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
出版信息
Onco Targets Ther. 2019 Sep 18;12:7685-7690. doi: 10.2147/OTT.S216161. eCollection 2019.
Phosphatidylethanolamine-binding protein 4 (PEBP4) has been found to be highly expressed in many tumors and to be closely related to the proliferation, differentiation, and metastasis of tumors. PEBP4 has also been found to be involved in many cancer-activated signaling pathways and to cause therapeutic resistance. In this study, we first reviewed the morphological structure and expression of PEBP4, then discussed the roles of PEBP4 in individualized treatment of some cancers, and finally explored the possibilities of cultivating PEBP4 as a therapeutic target.We also identified the main signaling pathways in which PEBP4 affects different cancers. It is here concluded that over-expression of PEBP4 can enhance the proliferation and metastasis of the cancer cells and the resistance to radiotherapy/chemotherapy in cancers.
磷脂酰乙醇胺结合蛋白4（PEBP4）已被发现在许多肿瘤中高表达，且与肿瘤的增殖、分化和转移密切相关。还发现PEBP4参与许多癌症激活的信号通路，并导致治疗耐药性。在本研究中，我们首先综述了PEBP4的形态结构和表达，然后讨论了PEBP4在某些癌症个体化治疗中的作用，最后探讨了将PEBP4培育为治疗靶点的可能性。我们还确定了PEBP4影响不同癌症的主要信号通路。由此得出结论，PEBP4的过表达可增强癌细胞的增殖和转移以及癌症对放疗/化疗的耐药性。
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